硫酸葡聚糖对透明质酸酶的抑制作用及其在抗癌治疗中的可能应用。
Inhibition of hyaluronidase by dextran sulfate and its possible application in anticancer treatment.
作者信息
Zimmermann K, Preinl G, Ludwig H, Greulich K O
出版信息
J Cancer Res Clin Oncol. 1983;105(2):189-90. doi: 10.1007/BF00406931.
Abstract
Hyaluronidase is competitively inhibited by dextran sulfate. Hyaluronidase depolymerizes the amorphous component of the interstitial connective tissue and therefore supports tumor spread and metastasis. These processes may be reduced by dextran sulfate.
摘要
硫酸葡聚糖可竞争性抑制透明质酸酶。透明质酸酶能使间质结缔组织的无定形成分解聚，从而促进肿瘤扩散和转移。硫酸葡聚糖可能会减少这些过程。
相似文献
1
Inhibition of hyaluronidase by dextran sulfate and its possible application in anticancer treatment.硫酸葡聚糖对透明质酸酶的抑制作用及其在抗癌治疗中的可能应用。
J Cancer Res Clin Oncol. 1983;105(2):189-90. doi: 10.1007/BF00406931.
2
Effects of hyaluronidase on doxorubicin penetration into squamous carcinoma multicellular tumor spheroids and its cell lethality.透明质酸酶对阿霉素渗透入鳞状细胞癌多细胞肿瘤球体的影响及其细胞致死率。
J Cancer Res Clin Oncol. 1994;120(5):293-7. doi: 10.1007/BF01236386.
3
Synthesis and optimization of fluoxetine-loaded polymeric nanoparticles for dual therapeutic applications in cancer and depression.用于癌症和抑郁症双重治疗应用的载氟西汀聚合物纳米颗粒的合成与优化。
Daru. 2025 Jun 4;33(2):18. doi: 10.1007/s40199-025-00561-2.
4
DS-Modified Paeoniflorin pH-Responsive Lipid-Polymer Hybrid Nanoparticles for Targeted Macrophage Polarization in a Rat Model of Rheumatoid Arthritis.用于类风湿性关节炎大鼠模型中靶向巨噬细胞极化的DS修饰芍药苷pH响应性脂质-聚合物杂化纳米颗粒
Int J Nanomedicine. 2025 Jul 12;20:8967-8992. doi: 10.2147/IJN.S516434. eCollection 2025.
5
Hyaluronidase: structure, mechanism of action, diseases and therapeutic targets.透明质酸酶：结构、作用机制、疾病及治疗靶点
Mol Biomed. 2025 Jul 12;6(1):50. doi: 10.1186/s43556-025-00299-y.
6
Use of hyaluronidase as an adjunct to local anaesthetic eye blocks to reduce intraoperative pain in adults.透明质酸酶作为局部麻醉性眼部阻滞辅助药物用于减轻成人术中疼痛。
Cochrane Database Syst Rev. 2018 Mar 2;3(3):CD010368. doi: 10.1002/14651858.CD010368.pub2.
7
Dextrans as anticoagulants and antiplatelet agents: protocol for a scoping review.作为抗凝剂和抗血小板药物的右旋糖酐：一项范围综述方案
BMJ Open. 2025 Jun 30;15(6):e092284. doi: 10.1136/bmjopen-2024-092284.
8
Potential Ligands to Resistin Against Prostate Cancer, Evaluated by Molecular Docking and In Vitro Assays to Develop an Anticancer Drug.通过分子对接和体外试验评估抵抗素的潜在配体以开发抗癌药物用于前列腺癌治疗
Chem Biodivers. 2025 Jun;22(6):e202500189. doi: 10.1002/cbdv.202500189. Epub 2025 Feb 17.
9
Inhaled magnesium sulfate in the treatment of acute asthma.吸入硫酸镁治疗急性哮喘。
Cochrane Database Syst Rev. 2017 Nov 28;11(11):CD003898. doi: 10.1002/14651858.CD003898.pub6.
10
Novel indole Schiff base β-diiminato compound as an anti-cancer agent against triple-negative breast cancer: In vitro anticancer activity evaluation and in vivo acute toxicity study.新型吲哚席夫碱β-二亚胺化合物作为一种针对三阴性乳腺癌的抗癌剂：体外抗癌活性评价和体内急性毒性研究。
Bioorg Chem. 2024 Nov;152:107730. doi: 10.1016/j.bioorg.2024.107730. Epub 2024 Aug 16.
引用本文的文献
1
Inhibition of hyaluronan degradation by dextran sulphate facilitates characterisation of hyaluronan synthesis: an in vitro and in vivo study.硫酸葡聚糖对透明质酸降解的抑制作用有助于透明质酸合成的表征：一项体外和体内研究。
Glycoconj J. 2004;20(7-8):461-71. doi: 10.1023/B:GLYC.0000038292.71098.35.
2
Expression of hyaluronidase by tumor cells induces angiogenesis in vivo.肿瘤细胞中透明质酸酶的表达可在体内诱导血管生成。
Proc Natl Acad Sci U S A. 1996 Jul 23;93(15):7832-7. doi: 10.1073/pnas.93.15.7832.
本文引用的文献
1
Inhibition of hyaluronidase.透明质酸酶的抑制作用。
Physiol Rev. 1955 Apr;35(2):381-402. doi: 10.1152/physrev.1955.35.2.381.
2
TOXICITY OF HEPARINOIDS, WITH SPECIAL REFERENCE TO THE PRECIPITATION OF FIBRINOGEN.类肝素的毒性，特别涉及纤维蛋白原的沉淀
Thromb Diath Haemorrh. 1964 Oct 15;12:232-61.
3
Investigation of the toxicity of a series of dextran sulphates of varying molecular weight.一系列不同分子量硫酸葡聚糖的毒性研究。
Br J Pharmacol Chemother. 1954 Mar;9(1):1-14. doi: 10.1111/j.1476-5381.1954.tb00809.x.
4
Inhibition of experimental blood-borne lung metastasis by protease inhibitors.蛋白酶抑制剂对实验性血行性肺转移的抑制作用。
Cancer Res. 1980 Jul;40(7):2539-42.
5
[Collagenolytic activity of neoplastic and rapidly proliferating normal tissue].[肿瘤组织和快速增殖的正常组织的胶原酶活性]
Onkologie. 1981 Feb;4(1):30-2. doi: 10.1159/000214872.
6
On the prevention of haematogenous tumor metastases rats. The role of the proteinase inhibitor "Trasylol".关于大鼠血源性肿瘤转移的预防。蛋白酶抑制剂“抑肽酶”的作用。
J Cancer Res Clin Oncol. 1980;97(2):129-35. doi: 10.1007/BF00409898.
7
A permeability-enhancing factor produced by tumor. The genesis of malignant effusions.一种由肿瘤产生的通透性增强因子。恶性积液的成因。
J Cancer Res Clin Oncol. 1980;97(3):315-20. doi: 10.1007/BF00405784.
8
Sulfation of dextran with piperidine-N-sulfonic acid.
Carbohydr Res. 1972 Mar;21(3):420-6. doi: 10.1016/s0008-6215(00)84922-8.
9
Decrease of saturation density in cultured tumor cells by dextran sulfate.硫酸葡聚糖降低培养肿瘤细胞中的饱和密度。
Gan. 1972 Jun;63(3):371-4.
10
Lymphosarcoma cell growth is selectively inhibited by B lymphocyte mitogens: LPS, dextran sulfate and PPD.淋巴细胞有丝分裂原：脂多糖、硫酸葡聚糖和结核菌素纯蛋白衍生物可选择性抑制淋巴肉瘤细胞的生长。
Biochem Biophys Res Commun. 1974 Dec 23;61(4):1268-75. doi: 10.1016/s0006-291x(74)80421-3.
Zotero 插件