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一种由肿瘤产生的通透性增强因子。恶性积液的成因。

A permeability-enhancing factor produced by tumor. The genesis of malignant effusions.

作者信息

Stein-Werblowsky R

出版信息

J Cancer Res Clin Oncol. 1980;97(3):315-20. doi: 10.1007/BF00405784.

Abstract

The intra-articular injection of ascites fluid or of extracts derived from malignant tumors was shown to induce exudative joint lesions. The intra-articular injection of normal plasma did not have this effect. It is suggested that tumor secretes a permeability-enhancing agent. This substance promotes the extravasation of humoral or cellular elements into the joint spaces. A similar mechanism may underlie the development of pulmonary arthropathy or the formation of malignant effusions.

摘要

关节腔内注射腹水或恶性肿瘤提取物可导致渗出性关节病变。关节腔内注射正常血浆则无此作用。提示肿瘤分泌一种通透性增强剂。该物质促进体液或细胞成分渗入关节腔。类似机制可能是肺性关节病发生或恶性积液形成的基础。

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