Motz W, Ploeger M, Ringsgwandl G, Goeldel N, Garthoff B, Kazda S, Strauer B E
J Cardiovasc Pharmacol. 1983 Jan-Feb;5(1):55-61. doi: 10.1097/00005344-198301000-00008.
We compared left ventricular (LV) hemodynamics, LV muscle mass (LVMM), and LV geometry of 13 spontaneously hypertensive rats (SHRs) treated for 20 weeks with nifedipine (30 mg/kg/day) with those of 11 age-matched untreated SHRs. LVMM, LVMM related to end-diastolic volume (LVMM/EDV), LV pressure (PLV), systolic wall stress (Tsyst), ejection fraction (EF), cardiac index (CI), and isovolumetric contractility indices (dP/dtmax, IP, t-dP/dtmax, and VCE) were determined. Nifedipine treatment lowered PLV from 170 to 136 mm Hg and Tsyst from 222 to 194 10(3) dyn/cm2. LVMM and LVMM/EDV decreased moderately from 800 to 744 mg and from 2.56 to 2.29 mg/microliter, respectively. Left ventricular ejection was markedly increased (EF from 52 to 64%; CI from 154 to 178 ml/min X kg), whereas isovolumic contractility indices remained unchanged. Thus, nifedipine reduced but did not totally prevent myocardial hypertrophy and enhanced LV function. These effects seem to result from reduction in LV afterload and not from altered myocardial contractility.
我们比较了13只经硝苯地平（30毫克/千克/天）治疗20周的自发性高血压大鼠（SHR）与11只年龄匹配的未经治疗的SHR的左心室（LV）血流动力学、左心室肌肉质量（LVMM）和左心室几何形状。测定了LVMM、与舒张末期容积相关的LVMM（LVMM/EDV）、左心室压力（PLV）、收缩期壁应力（Tsyst）、射血分数（EF）、心脏指数（CI）和等容收缩性指数（dP/dtmax、IP、t-dP/dtmax和VCE）。硝苯地平治疗使PLV从170毫米汞柱降至136毫米汞柱，使Tsyst从222×10³达因/平方厘米降至194×10³达因/平方厘米。LVMM和LVMM/EDV分别从800毫克适度降至744毫克，从2.56毫克/微升降至2.29毫克/微升。左心室射血明显增加（EF从52%增至64%；CI从154毫升/分钟×千克增至178毫升/分钟×千克），而等容收缩性指数保持不变。因此，硝苯地平减轻但未完全预防心肌肥厚，并增强了左心室功能。这些作用似乎是由于左心室后负荷降低，而非心肌收缩性改变所致。
