Motz W, Strauer B E
Hypertension. 1983 Jul-Aug;5(4 Pt 2):II39-44. doi: 10.1161/01.hyp.5.4_pt_2.ii39.
Left ventricular (LV) hemodynamics, LV muscle mass, and LV geometry of 28 spontaneously hypertensive rats (SHR) treated for 20, 40, and 60 weeks with nifedipine (30 mg/kg/day) were compared with those of 29 age-matched untreated SHR. LV Pressure (PLV), systolic wall stress (Tsyst), ejection fraction (EF), cardiac index (CI), the ratio of LV muscle mass to body weight (LV/BW) and the ratio of LV muscle mass to end-diastolic volume (M/V) were determined. Myocardial contractility was analyzed through studies of the isolated LV papillary muscle. After 60 weeks of nifedipine treatment, PLV was 32.2% and Tsyst 22.9% lower in the treated group compared to the untreated control group (PLV 116 vs 171 mm Hg; Tsyst 165 vs 214 10(3)dyn/cm2). The degree of LV hypertrophy as indicated by LV/BW (-14%) and M/V (-21%) was less after treatment. LV pumping performance was considerably improved (EF = from 54% to 61%; Cl = from 175 to 220 ml/kg), whereas myocardial contractility indices such as maximum isotonic shortening velocity and isometric tension development remained unchanged. Thus, nifedipine reduced cardiac hypertrophy and improved LV function. These effects seem to result from a reduction in LV afterload.
将28只自发性高血压大鼠（SHR）用硝苯地平（30毫克/千克/天）治疗20周、40周和60周后的左心室（LV）血流动力学、LV肌肉质量和LV几何结构，与29只年龄匹配的未治疗SHR进行比较。测定LV压力（PLV）、收缩期壁应力（Tsyst）、射血分数（EF）、心脏指数（CI）、LV肌肉质量与体重之比（LV/BW）以及LV肌肉质量与舒张末期容积之比（M/V）。通过对分离的LV乳头肌的研究分析心肌收缩性。硝苯地平治疗60周后，治疗组的PLV比未治疗的对照组低32.2%，Tsyst低22.9%（PLV 116对171毫米汞柱；Tsyst 165对214×10³达因/平方厘米）。治疗后，LV/BW（-14%）和M/V（-21%）所示的LV肥厚程度减轻。LV泵血功能显著改善（EF = 从54%提高到61%；Cl = 从175提高到220毫升/千克），而心肌收缩性指标如最大等张缩短速度和等长张力发展保持不变。因此，硝苯地平减轻了心脏肥厚并改善了LV功能。这些作用似乎是由于LV后负荷降低所致。
