化学诱变剂对黑腹果蝇神经节染色体畸变的诱导作用。

Induction of chromosome aberrations by chemical mutagens in neural ganglia of Drosophila melanogaster.

作者信息

De Marco A, Polani S

出版信息

Mutat Res. 1983 Jan;107(1):93-102. doi: 10.1016/0027-5107(83)90080-5.

DOI:10.1016/0027-5107(83)90080-5

Abstract

Chromatid aberrations induced by various concentrations of bleomycin, cyclophosphamide and mitomycin C were analyzed in neural ganglia of third-instar larvae of Drosophila melanogaster. A clear dose response was observed with increasing dose after treatment with bleomycin and mitomycin C, whereas no effect was observed after treatment with cyclophosphamide. A comparison with published data for the induction of sex-linked recessive lethals showed that, at least for the 3 drugs tested, the use of both tests eliminates false negatives and might comprise a useful procedure for testing mutagenicity in Drosophila.

摘要

在黑腹果蝇三龄幼虫的神经节中，分析了不同浓度的博来霉素、环磷酰胺和丝裂霉素C诱导的染色单体畸变。在用博来霉素和丝裂霉素C处理后，随着剂量增加观察到明显的剂量反应，而在用环磷酰胺处理后未观察到影响。与已发表的关于性连锁隐性致死诱导的数据比较表明，至少对于所测试的这3种药物，两种测试的使用消除了假阴性，可能构成一种在果蝇中测试致突变性的有用方法。

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