Eckels D D, Lake P, Lamb J R, Johnson A H, Shaw S, Woody J N, Hartzman R J
Nature. 1983 Feb 24;301(5902):716-8. doi: 10.1038/301716a0.
The HLA-D region of the human major histocompatibility complex (MHC) has been shown to be homologous to the murine I region in terms of both structure and function. Both regions encode class II MHC molecules which restrict T-lymphocyte interactions with antigen-presenting cells. We have recently described the MHC restriction and antigen specificities of human T-lymphocyte clones directed at strain A influenza virus. The majority of T-lymphocyte clones recognized antigen in the context of cell surface interaction products encoded by HLA-D/DR genes. However, a few clones recognized antigen presented by cells histoincompatible for D/DR antigens. We report here that some of these clones recognized viral antigens in association with antigens encoded by genes identical with or closely linked to the recently described secondary B-cell (SB) locus of the MHC. This is the first report that SB-restricted antigen recognition may form an integral part of normal, human immune responses.
人类主要组织相容性复合体（MHC）的HLA - D区域在结构和功能方面均已显示出与小鼠I区域同源。这两个区域都编码II类MHC分子，这些分子限制T淋巴细胞与抗原呈递细胞的相互作用。我们最近描述了针对A型流感病毒的人类T淋巴细胞克隆的MHC限制和抗原特异性。大多数T淋巴细胞克隆在由HLA - D/DR基因编码的细胞表面相互作用产物的背景下识别抗原。然而，一些克隆识别由与MHC最近描述的二级B细胞（SB）基因座相同或紧密连锁的基因编码的抗原呈递细胞所呈递的抗原。我们在此报告，这些克隆中的一些识别与由与MHC最近描述的二级B细胞（SB）基因座相同或紧密连锁的基因编码的抗原相关的病毒抗原。这是关于SB限制的抗原识别可能构成正常人类免疫反应不可或缺的一部分的首次报告。
