Quatrini M, Basilisco G, Conte D, Bozzani A, Bardella M T, Bianchi P A
Am J Gastroenterol. 1983 Mar;78(3):149-51.
Somatostatin (4 micrograms/min, cyclic form) was infused for 24 h on six occasions in four patients with carcinoid ileal tumor and multiple liver metastases. During infusion, spontaneous flushes and/or diarrhea were markedly reduced with a return to the pretreatment pattern on the next day. Urinary 5-hydroxyindole acetic acid excretion and plasma gastrin were not significantly changed, whereas plasma insulin presented the expected decrease and rebound. These results confirm that carcinoid symptoms are somatostatin-sensitive but do not provide evidence that serotonin or gastrin play a major role in inducing these symptoms.
对4例患有类癌性回肠肿瘤并伴有多处肝转移的患者，分6次进行了24小时的生长抑素（4微克/分钟，环状形式）输注。输注期间，自发性潮红和/或腹泻明显减轻，次日恢复到治疗前的状态。尿5-羟吲哚乙酸排泄量和血浆胃泌素没有明显变化，而血浆胰岛素呈现出预期的下降和反弹。这些结果证实类癌症状对生长抑素敏感，但没有提供证据表明5-羟色胺或胃泌素在诱发这些症状中起主要作用。
