Davis G R, Camp R C, Raskin P, Krejs G J
Gastroenterology. 1980 Feb;78(2):346-9.
The effect of intravenous somatostatin infusion was investigated in a patient with severe secretory diarrhea due to malignant carcinoid syndrome. Continuous somatostatin infusion for 48 hr (4 microgram/kg/hr) reduced stool volume from 2.2 to 0.7 liters/day. Intestinal perfusion studies before intravenous somatostatin infusion revealed decreased water and sodium absorption and jejunal chloride secretion. Somatostatin infusion for 2 hr (8 microgram/kg/hr) reversed chloride secretion to absorption and markedly enhanced water and sodium absorption. These results suggest that somatostatin inhibited a secretory component of water and ion movement in the small bowel of the patient with malignant carcinoid syndrome.
对一名因恶性类癌综合征导致严重分泌性腹泻的患者进行了静脉输注生长抑素的效果研究。连续48小时（4微克/千克/小时）输注生长抑素使粪便量从每天2.2升减少至0.7升。静脉输注生长抑素前的肠道灌注研究显示水和钠吸收减少，空肠氯化物分泌增加。输注2小时（8微克/千克/小时）的生长抑素使氯化物分泌转变为吸收，并显著增强了水和钠的吸收。这些结果表明，生长抑素抑制了恶性类癌综合征患者小肠中水分和离子运动的分泌成分。
