Schanzlin D J, Cyr R J, Friedlaender M H
Arch Ophthalmol. 1983 Mar;101(3):472-4. doi: 10.1001/archopht.1983.01040010472030.
We have developed an experimental model for the quantitative examination of the kinetics of the inflammatory cell response to thermal corneal injury. Using this model, we found a considerable difference in the type of inflammatory cell response to vasculogenic (peripheral) and nonvasculogenic (central) thermal cautery of the cornea. We found that infiltration of the corneal stroma with polymorphonuclear leukocytes preceded the growth of blood vessels in this model. This quantitative model will be useful in future studies of the role of inflammatory cells in different models of corneal neovascularization, and may provide quantitative evidence of how known inhibitors of corneal neovascularization exert their effect.
我们已经开发出一种实验模型，用于定量检测炎性细胞对角膜热损伤的反应动力学。利用该模型，我们发现角膜血管生成性（周边）和非血管生成性（中央）热灼引起的炎性细胞反应类型存在显著差异。我们发现在该模型中，多形核白细胞浸润角膜基质先于血管生长。这种定量模型将有助于未来研究炎性细胞在不同角膜新生血管模型中的作用，并且可能为已知的角膜新生血管抑制剂如何发挥作用提供定量证据。
