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[抗凝血酶III浓缩物的制备与表征]

[Preparation and characterization of an antithrombin III concentrate].

作者信息

Dornheim G, Schön R

出版信息

Folia Haematol Int Mag Klin Morphol Blutforsch. 1982;109(6):870-7.

PMID:6187640
Abstract

Tri-calciumphosphate was found to have not only a known adsorption capacity for factors of the prothrombin complex, but also for antithrombin III. Depending on the inserted blood stabilizer the human plasma fractions Cohn I, PPSB and antithrombin III may be isolated from the same initial material in the area of the transfusion service. Enriching antithrombin III is achieved by a three-stage procedure under aseptic conditions in a closed system. Liberating antithrombin III from calciumphosphate is made with care without using any concentrated salt solutions.

摘要

已发现磷酸三钙不仅对凝血酶原复合物的因子具有已知的吸附能力,而且对抗凝血酶III也有吸附能力。根据所插入的血液稳定剂,在输血服务领域,可以从相同的初始材料中分离出人血浆组分科恩I、PPSB和抗凝血酶III。在封闭系统中,通过无菌条件下的三阶段程序实现抗凝血酶III的富集。从磷酸钙中释放抗凝血酶III时要小心操作,不使用任何浓盐溶液。

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