Oikawa T, Muramatsu Y, Akashi S, Usui N
Division of Nephrology, Saitama Children's Medical Center, Japan.
Nihon Jinzo Gakkai Shi. 1993 Oct;35(10):1163-9.
Decreased plasma level of antithrombin III was assumed to be one of the major factors underlying hypercoagulable state in nephrotic syndrome. Concentrated antithrombin III preparation was given to 8 children with nephrotic syndrome with a plasma antithrombin III activity of less than 70%, to evaluate the effect on hypercoagulable state. Plasma antithrombin III activity was elevated to more than 70% in 7 of 8 children after treatment, while plasma levels of plasmin-alpha 2 plasmin inhibitor complex and FDP-D dimer were not significantly decreased. One patient developed brain infarction after the treatment, suggesting that prophylactic administration of concentrated antithrombin III preparation is not fully protective against thrombotic complications in nephrotic syndrome.
抗凝血酶III血浆水平降低被认为是肾病综合征高凝状态的主要因素之一。对8名血浆抗凝血酶III活性低于70%的肾病综合征患儿给予浓缩抗凝血酶III制剂，以评估其对高凝状态的影响。治疗后8名患儿中有7名血浆抗凝血酶III活性升至70%以上，而血浆纤溶酶-α2纤溶酶抑制物复合物和FDP-D二聚体水平未显著降低。1例患儿治疗后发生脑梗死，提示预防性给予浓缩抗凝血酶III制剂不能完全预防肾病综合征的血栓并发症。
