Höcker P, Mann M, Pittermann E
Folia Haematol Int Mag Klin Morphol Blutforsch. 1982;109(6):921-32.
The present situation in thrombocyte and granulocyte substitution is presented. First, the different methods of producing thrombocyte and granulocyte concentrates are discussed. Differential centrifugation and cell separators with continuous or intermittent flow are used for gaining thrombocytes, whereas cell separators with continuous or intermittent flow as well as filtration and gravitation leucapheresis may be used for producing granulocyte concentrates. Then, the indications for substituting granulocytes and thrombocytes are discussed. For thrombocyte substitution, thrombocyte numbers below 20 X 10(9)/1 and haemorrhagic diathesis are considered as an absolute indication. Granulocyte concentrates should only be administered to patients with transitory marked granulocytopenia, with granulocytes being less than 0.2 X 10(9)/1 and ensured bacterial infection. Finally, future basic developments of thrombocyte and granulocyte substitution are discussed.
介绍了血小板和粒细胞替代的现状。首先，讨论了生产血小板和粒细胞浓缩物的不同方法。差速离心法以及连续或间歇流动的细胞分离器用于获取血小板，而连续或间歇流动的细胞分离器以及过滤和重力白细胞单采法可用于生产粒细胞浓缩物。然后，讨论了粒细胞和血小板替代的适应症。对于血小板替代，血小板计数低于20×10⁹/L和出血素质被视为绝对适应症。粒细胞浓缩物仅应给予短暂性明显粒细胞减少的患者，粒细胞低于0.2×10⁹/L且有明确的细菌感染。最后，讨论了血小板和粒细胞替代未来的基础发展。
