年轻、成年和老年大鼠实验性消耗后ATP和磷酸肌酸的恢复情况。

Restitution of ATP and creatine phosphate after experimental depletion in young, adult, and old rats.

作者信息

McNamara M C, Miller A T, Shen A L, Wood J J

出版信息

Gerontology. 1978;24(2):95-103. doi: 10.1159/000212241.

Abstract

The rates of restitution of skeletal muscle, heart, and brain creatine phosphate and brain ATP, following experimental depletion, were compared in young (3-5 month), adult (12 month) and old (24 month) rats. In skeletal muscle, restitution of creatine phosphate after 3 min of recovery was greatest in the young rats, minimal in the adult animals, and absent in the old animals. In heart muscle, on the other hand, restitution was rapid in all three age groups, and was essentially complete after 60 sec recovery. In brain, restitution of creatine phosphate was rapid and was complete after 10 min recovery in the young and adult rats; restitution was slower and less complete in the old rats. In the old rats there was no restitution of brain ATP during the first 2 min of recovery, after which the rate of restitution paralleled that of the young and adult rats.

摘要

在年轻（3 - 5个月）、成年（12个月）和老年（24个月）大鼠中，比较了实验性消耗后骨骼肌、心脏和大脑中磷酸肌酸以及大脑中三磷酸腺苷（ATP）的恢复速率。在骨骼肌中，恢复3分钟后，年轻大鼠磷酸肌酸的恢复程度最大，成年动物最小，老年动物则无恢复。另一方面，在心肌中，所有三个年龄组的恢复都很快，恢复60秒后基本完成。在大脑中，年轻和成年大鼠恢复10分钟后，磷酸肌酸的恢复迅速且完全；老年大鼠的恢复较慢且不完全。在老年大鼠中，恢复的前2分钟大脑ATP没有恢复，之后恢复速率与年轻和成年大鼠平行。