Milhaud P G, Faure T, Chaintreuil J, Cathala J M, Lebleu B
J Gen Virol. 1983 Feb;64 (Pt 2):485-9. doi: 10.1099/0022-1317-64-2-485.
Mouse fibroblast LM cells growing continuously in the absence of serum and exogenous lipids are proposed as a model for studying interferon action. Several of its activities, namely the inhibition of virus and cell growth, and the increased cytotoxicity of poly(rI) X poly(rC), are shown to be potentiated in such conditions. Since cells cultured under these conditions are devoid of precursors of prostaglandin biosynthesis, the data suggest that none of the three effects of interferon depends on active prostaglandin synthesis.
在无血清和外源性脂质条件下持续生长的小鼠成纤维细胞LM细胞被提议作为研究干扰素作用的模型。在这种条件下，其几种活性，即对病毒和细胞生长的抑制以及聚肌苷酸-聚胞苷酸（poly(rI)X poly(rC)）细胞毒性的增加，均被证明得到增强。由于在这些条件下培养的细胞缺乏前列腺素生物合成的前体，这些数据表明干扰素的三种作用均不依赖于活跃的前列腺素合成。
