Clarke B E, Ham K N, Tange J D, Ryan G B
J Pathol. 1983 Mar;139(3):247-58. doi: 10.1002/path.1711390303.
The origin of glomerular crescents was investigated in an accelerated model of rabbit nephrotoxic nephritis. In rabbits immunised against sheep gamma-globulin, the administration of sheep nephrotoxic serum provoked cellular crescent formation affecting 30 to 90 per cent. of glomeruli at 6 days. The crescents were composed predominantly of cells with ultrastructural features of macrophages. In animals depleted of circulating leukocytes by whole body irradiation, with or without shielding of the kidney, crescent formation was inhibited despite severe glomerular damage and fibrin deposition in Bowman's space. These findings support the hypothesis that glomerular crescents develop principally from the emigration and accumulation of bone marrow-derived mononuclear cells.
在兔肾毒性肾炎加速模型中研究了肾小球新月体的起源。在对绵羊γ球蛋白免疫的兔中，给予绵羊肾毒性血清可引发细胞新月体形成，在第6天时累及30%至90%的肾小球。新月体主要由具有巨噬细胞超微结构特征的细胞组成。在通过全身照射使循环白细胞耗竭的动物中，无论是否对肾脏进行屏蔽，尽管肾小球严重受损且鲍曼间隙中有纤维蛋白沉积，但新月体形成仍受到抑制。这些发现支持了肾小球新月体主要由骨髓来源的单核细胞迁移和聚集形成的假说。
