Reznik-Schüller H M, Gregg M
Anticancer Res. 1982 Nov-Dec;2(6):381-4.
Male F344 rats were given N-nitrosoheptamethyleneimine (NHMI) twice a week by gavage for 20 weeks. They developed peripheral squamous cell carcinomas of the lungs. Electron microscopy revealed the presence of mature keratin in the tumor centers and the formation of keratohyalin granules in the more peripheral tumor cells. Basal cells were identified as the actively growing component of the neoplasms. In contrast to NHMI-induced lung carcinomas in European hamsters, neither Clara, nor APUD-type, cells were found in the rat tumors. These data indicate that the mode of development of NHMI-induced lung tumors is different in these two species.
雄性F344大鼠每周两次经口灌胃给予N-亚硝基庚亚甲基亚胺（NHMI），持续20周。它们发生了肺部外周鳞状细胞癌。电子显微镜检查显示肿瘤中心存在成熟角蛋白，且在外周肿瘤细胞中形成了透明角质颗粒。基底细胞被确定为肿瘤的活跃生长成分。与欧洲仓鼠中NHMI诱导的肺癌不同，在大鼠肿瘤中未发现克拉拉细胞或APUD型细胞。这些数据表明，NHMI诱导的肺肿瘤在这两个物种中的发生模式不同。
