Reznik-Schüller H
J Pathol. 1977 Feb;121(2):79-82. doi: 10.1002/path.1711210203.
Groups of Syrian golden hamsters were treated twice weekly for life with 1/10 LD50 DEN, or once weekly for life with 1/5 LD50 DBN. The sequential alterations in the ultrastructure of Apud cells in their bronchial lining were examined. Both carcinogens caused pronounced proliferation of this cell type during the initial treatment period. Thereafter, the formation of increasing numbers of filamentous bundles was observed in the cytoplasm of the Apud cells, whereas their neurosecretory granules decreased in number. The present findings suggest that after an initial phase of proliferation, the Apud cells undergo squamous metaplasia when treated with the two nitrosamines investigated.
将叙利亚金黄地鼠分组，每周两次终身给予1/10 LD50的二乙基亚硝胺（DEN），或每周一次终身给予1/5 LD50的N-二甲基亚硝胺（DBN）。研究了其支气管内衬中APUD细胞超微结构的连续变化。两种致癌物在初始治疗期间均导致这种细胞类型明显增殖。此后，在APUD细胞的细胞质中观察到丝状束数量增加，而其神经分泌颗粒数量减少。目前的研究结果表明，在用所研究的两种亚硝胺处理后，APUD细胞在经历初始增殖阶段后会发生鳞状化生。
