Ting S, Zweiman B, Lavker R
J Allergy Clin Immunol. 1983 May;71(5):437-41. doi: 10.1016/0091-6749(83)90458-x.
Terbutaline, a preferential beta 2-adrenergic agonist, has been shown to inhibit allergen-induced histamine release in vitro. In contrast, orally administered therapeutic doses of terbutaline do not inhibit antigen-induced wheal and flare reactions. We studied the effects of local terbutaline on antigen-induced whealing response, histamine release, cellular inflammatory response, and ultramicroscopic mast cell changes in antigen-challenged skin sites in ragweed-sensitive subjects. Results showed that ragweed challenge significantly induced increased histamine release in all subjects. In contrast, no such histamine release was observed at sites challenged with antigen in the presence of terbutaline. Thus locally applied terbutaline in nontoxic doses modulates mediator release in certain allergic reactions.
特布他林是一种选择性β2肾上腺素能激动剂，已证实在体外可抑制变应原诱导的组胺释放。相比之下，口服治疗剂量的特布他林并不能抑制抗原诱导的风团和潮红反应。我们研究了局部应用特布他林对豚草敏感受试者抗原激发皮肤部位抗原诱导的风团反应、组胺释放、细胞炎症反应及超微结构肥大细胞变化的影响。结果显示，豚草激发在所有受试者中均显著诱导组胺释放增加。相比之下，在特布他林存在的情况下，抗原激发部位未观察到此类组胺释放。因此，局部应用无毒剂量的特布他林可调节某些过敏反应中的介质释放。
