Ting S, Zweiman B, Lavker R M
J Allergy Clin Immunol. 1983 Jan;71(1 Pt 1):12-7. doi: 10.1016/0091-6749(83)90540-7.
Cromolyn pretreatment frequently reduces antigen inhalation-induced bronchospasm possibly by inhibiting mast cell degranulation and mediator release. However, the local effects of cromolyn on type I hypersensitivity skin reactions are not well understood. We studied the effect of local cromolyn on antigen-induced skin reaction, histamine release, cellular inflammatory response, and ultramicroscopic changes of mast cells in 10 ragweed-sensitized subjects. Results showed that cromolyn 2% (nonirritant dose) does not modulate ragweed-induced skin whealing response, histamine release, and ultramicroscopic changes of mast cells. Thus, unlike the situation in the tracheobronchial tree, allergic skin reactions and associated events are not inhibited by local cromolyn application.
色甘酸钠预处理常常能减轻抗原吸入诱发的支气管痉挛，这可能是通过抑制肥大细胞脱颗粒和介质释放来实现的。然而，色甘酸钠对I型超敏皮肤反应的局部作用尚不清楚。我们研究了局部应用色甘酸钠对10名豚草致敏受试者的抗原诱发皮肤反应、组胺释放、细胞炎症反应以及肥大细胞超微结构变化的影响。结果显示，2%的色甘酸钠（无刺激剂量）不会调节豚草诱发的皮肤风团反应、组胺释放以及肥大细胞的超微结构变化。因此，与气管支气管树的情况不同，局部应用色甘酸钠不会抑制过敏性皮肤反应及相关事件。
