Jackson C V, Carrier G O
J Cardiovasc Pharmacol. 1983 Mar-Apr;5(2):260-5. doi: 10.1097/00005344-198303000-00016.
Hypertension, atherosclerosis, arteriosclerosis, and cardiomyopathy account for 80% of all diabetic deaths. A paucity of data exists concerning reactivity of the diabetic vasculature to vasopressor substances. The purpose of this investigation was to determine the influence of short-term (4-5 weeks) diabetes on the responsiveness of the cardiovascular system to vasopressor substances in the intact conscious rat. Diabetes was chemically induced with streptozotocin (65 mg/kg i.v.) in 42-43-days-old, nonfasted, male Sprague-Dawley--derived rats. Direct blood pressure and heart rate were recorded, and responses to the vasopressor agonists norepinephrine and angiotensin II were obtained. Short-term diabetic rats were hypotensive and had lower heart rates when compared with control rats. Blood pressure responses to norepinephrine and angiotensin II were depressed in the short-term diabetic rat; however, the baroreceptor reflexes in these rats were more sensitive to increases in blood pressure. Therefore, it appears that there is some type of nonspecific alteration in the responsiveness of the cardiovascular system to the vasopressor agonists in the short-term diabetic rat.
高血压、动脉粥样硬化、动脉硬化和心肌病占所有糖尿病死亡病例的80%。关于糖尿病血管系统对血管加压物质的反应性，现有数据较少。本研究的目的是确定短期（4 - 5周）糖尿病对完整清醒大鼠心血管系统对血管加压物质反应性的影响。在42 - 43日龄、非禁食的雄性斯普拉格 - 道利大鼠中，用链脲佐菌素（65 mg/kg静脉注射）化学诱导糖尿病。记录直接血压和心率，并获得对血管加压激动剂去甲肾上腺素和血管紧张素II的反应。与对照大鼠相比，短期糖尿病大鼠血压较低且心率较慢。短期糖尿病大鼠对去甲肾上腺素和血管紧张素II的血压反应降低；然而，这些大鼠的压力感受器反射对血压升高更敏感。因此，短期糖尿病大鼠心血管系统对血管加压激动剂的反应性似乎存在某种非特异性改变。
