Gierhake F W
Langenbecks Arch Chir. 1982;358:167-71. doi: 10.1007/BF01271775.
Continuous prophylactic therapy with antibiotics has been used for a long time to try to prevent the step from bacterial contamination to clinical infection of surgical wounds. Earlier results of clinical trials were poor and side-effects common. For those used in recent years, however, the side-effects of pre- or perioperative prophylactic antibiotics have been minimal, although the therapeutical benefits have not yet been proven. This has also been the case with prophylactic infusion of gamma-globulin for prevention of postoperative wound infections.
长期以来,一直使用抗生素进行持续预防性治疗,试图防止手术伤口从细菌污染发展为临床感染。早期临床试验结果不佳,且副作用常见。然而,对于近年来使用的抗生素,术前或围手术期预防性使用抗生素的副作用已降至最低,尽管其治疗效果尚未得到证实。预防性输注丙种球蛋白以预防术后伤口感染的情况也是如此。