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1
Topical ampicillin in the appendicectomy wound: report of double-blind trial.阑尾切除术后伤口局部应用氨苄西林：双盲试验报告。
Br Med J. 1969 Oct 25;4(5677):206-7. doi: 10.1136/bmj.4.5677.206.
2
Wound infections after appendicectomy. I. A controlled trial on the prophylactic efficacy of topical ampicillin in non-perforated appendicitis. II. A controlled trial on the prophylactic efficacy of delayed primary suture and topical ampicillin in perforated appendicitis.
Acta Chir Scand. 1972;138(5):531-6.
3
Wound infection in emergency appendicectomy: a prospective trial with tropical ampicillin and antiseptic solution irrigation.
Br J Surg. 1978 Feb;65(2):89-91. doi: 10.1002/bjs.1800650206.
4
Septic complications after appendicectomy for perforated appendicitis. A controlled clinical trial metronidazole and topical ampicillin.穿孔性阑尾炎阑尾切除术后的感染性并发症。甲硝唑与局部用氨苄西林的对照临床试验。
Acta Chir Scand. 1983;149(5):517-20.
5
Topical ampicillin in the prevention of wound infection after appendicectomy.
Br J Surg. 1974 Jun;61(6):489-92. doi: 10.1002/bjs.1800610618.
6
Topical ampicillin and noxythiolin antisepsis in appendicectomy wounds.
Br J Clin Pract. 1973 Feb;27(2):57-61.
7
Appendix diameter: a predictor of wound infection after laparoscopic appendectomy.阑尾直径：腹腔镜阑尾切除术后伤口感染的一个预测指标。
Am Surg. 2011 Mar;77(3):307-10.
8
Decreased incidence of post-appendectomy wound abscesses due to local application of ampicillin.
Arch Chir Neerl. 1973;25(1):19-25.
9
Combined topical and systemic antibiotic prophylaxis in acute appendicitis.急性阑尾炎的局部与全身联合抗生素预防治疗
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Antibiotics versus placebo for prevention of postoperative infection after appendicectomy.抗生素与安慰剂预防阑尾切除术后感染的比较
Cochrane Database Syst Rev. 2001(2):CD001439. doi: 10.1002/14651858.CD001439.

引用本文的文献

1
Prophylaxis against sepsis in patients undergoing major surgery.重大手术患者败血症的预防。
World J Surg. 1993 Mar-Apr;17(2):178-83. doi: 10.1007/BF01658924.
2
Prophylaxis of infection after appendicectomy: a survey of current surgical practice.阑尾切除术后感染的预防：当前外科手术实践调查
Br Med J. 1980 Dec 13;281(6255):1597-600. doi: 10.1136/bmj.281.6255.1597.
3
The proper use of local antimicrobial agents in wounds.
World J Surg. 1980 Jul;4(4):433-7. doi: 10.1007/BF02393169.
4
Antimicrobial prophylaxis in appendectomy patients.阑尾炎手术患者的抗菌预防
World J Surg. 1982 May;6(3):306-11. doi: 10.1007/BF01653546.
5
Metronidazole v ampicillin: differing effects on the postoperative recovery.甲硝唑与氨苄西林：对术后恢复的不同影响。
Ann R Coll Surg Engl. 1984 Mar;66(2):96-7.
6
Wound infections in appendicitis: effective prophylaxis.
World J Surg. 1984 Jun;8(3):287-92. doi: 10.1007/BF01655054.
7
Wound infection rates after intraincisional plus systemic antibiotic prophylaxis in an animal model.
Eur J Clin Microbiol. 1984 Dec;3(6):538-41. doi: 10.1007/BF02013614.
8
[Infected wounds].[感染伤口]
Langenbecks Arch Chir. 1982;358:167-71. doi: 10.1007/BF01271775.
9
Topical ampicillin against wound infection after colorectal surgery.局部应用氨苄西林预防结直肠手术后伤口感染
Ann Surg. 1972 Aug;176(2):129-32. doi: 10.1097/00000658-197208000-00001.
10
Bacterial flora of the appendix fossa in appendicitis and postoperative wound infection.阑尾炎及术后伤口感染时阑尾隐窝的细菌菌群
J Clin Pathol. 1974 Dec;27(12):997-1000. doi: 10.1136/jcp.27.12.997.

本文引用的文献

1
Appendicitis--a report on its social pathology and recent surgical experience.
Br J Surg. 1950 Jul;38(149):52-64. doi: 10.1002/bjs.18003814911.
2
An experimental evaluation of methods used to prevent infection in wounds which have been contaminated with feces.对用于预防已被粪便污染的伤口感染的方法进行的实验评估。
Ann Surg. 1960 Jun;151(6):912-6. doi: 10.1097/00000658-196006000-00015.
3
PROPHYLACTIC TOPICAL USE OF ANTIBIOTICS IN SURGICAL WOUNDS: A CONTROLLED CLINICAL TRIAL USING "POLYBACTRIN".
Med J Aust. 1965 Jul 24;2(4):159-61.
4
THE PROPHYLAXIS OF SURGICAL INFECTION: THE EFFECT OF PROPHYLACTIC ANTIMICROBIAL DRUGS ON THE INCIDENCE OF INFECTION FOLLOWING POTENTIALLY CONTAMINATED OPERATIONS.外科感染的预防：预防性抗菌药物对潜在污染手术后感染发生率的影响。
Surgery. 1964 Jul;56:151-7.
5
APPENDICECTOMY WOUND INFECTION, DRAINAGE, AND ANTIBIOTICS.阑尾切除术伤口感染、引流及抗生素使用
Br J Surg. 1964 May;51:328-31. doi: 10.1002/bjs.1800510505.
6
WOUND SEPSIS AFTER CLEAN OPERATIONS.清洁手术后的伤口脓毒症
Lancet. 1964 May 16;1(7342):1095-7. doi: 10.1016/s0140-6736(64)91291-7.
7
Surgical sepsis: analysis of factors associated with sepsis following appendectomy (1937-1959).手术性脓毒症：阑尾切除术后脓毒症相关因素分析（1937 - 1959年）
Ann Surg. 1962 Nov;156(5):703-12. doi: 10.1097/00000658-196211000-00001.
8
Staphylococal infection of operation wounds with special reference to topical antibiotic prophylaxis.手术伤口的葡萄球菌感染，特别提及局部抗生素预防
Lancet. 1961 Sep 2;2(7201):505-9. doi: 10.1016/s0140-6736(61)92952-x.
9
A reappraisal of the effects of antimicrobial therapy on the course of appendicitis in children.抗菌治疗对儿童阑尾炎病程影响的重新评估。
Am Surg. 1961 Jan;27:29-32.
10
Prophylactic postoperative antibiotics; a controlled study of 1,007 cases.术后预防性使用抗生素；1007例病例的对照研究。
AMA Arch Surg. 1959 Aug;79(2):190-6.

阑尾切除术后伤口局部应用氨苄西林：双盲试验报告。

Topical ampicillin in the appendicectomy wound: report of double-blind trial.

作者信息

Rickett J W, Jackson B T

出版信息

Br Med J. 1969 Oct 25;4(5677):206-7. doi: 10.1136/bmj.4.5677.206.

DOI:10.1136/bmj.4.5677.206
PMID:4900147
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1629853/
Abstract

One hundred and thirty unselected patients undergoing appendicectomy were treated with topical ampicillin powder or topical placebo powder (lactose) before closing the wound. The postoperative wound infection rates were 3% in the ampicillin-treated group and 24% in the control group, a significant difference. This difference was not influenced by the degree of inflammation in the appendix. No side-effects of treatment were observed.

摘要

130例未经过挑选的接受阑尾切除术的患者在关闭伤口前接受了局部氨苄青霉素粉末或局部安慰剂粉末（乳糖）治疗。氨苄青霉素治疗组的术后伤口感染率为3%，而对照组为24%，差异显著。这种差异不受阑尾炎症程度的影响。未观察到治疗的副作用。