Joy R M
Neurobehav Toxicol Teratol. 1982 Nov-Dec;4(6):813-23.
A mode of action for lindane, dieldrin and related chlorinated hydrocarbon insecticides is proposed. The available evidence suggests that these insecticides act upon neurons in a global manner. Their primary target is the synapse, and they act there to intensify synaptic activity, primarily by enhancing transmitter release from the presynaptic terminal. All neurons appear to be affected. There is no apparent predilection for excitatory or inhibitory systems in the nervous system nor is there evidence for a specific action upon a single neurotransmitter or neurotransmitter system. It is proposed that the modifications that occur in behavior are based upon this same mode of action. A simplified model of brain plasticity, the kindled seizure model, is described as a potential tool for further investigation.
提出了林丹、狄氏剂及相关氯代烃杀虫剂的一种作用模式。现有证据表明，这些杀虫剂以一种全身性方式作用于神经元。它们的主要靶点是突触，在突触处发挥作用以增强突触活动，主要是通过增强突触前终末的递质释放。所有神经元似乎都会受到影响。对神经系统中的兴奋性或抑制性系统没有明显的偏好，也没有证据表明对单一神经递质或神经递质系统有特异性作用。有人提出，行为中出现的改变是基于这种相同的作用模式。描述了一种简化的脑可塑性模型——点燃癫痫模型，作为进一步研究的潜在工具。
