Dunn F, Soria J, Soria C, Thomaidis A, Tobelem G, Caen J P
Thromb Res. 1983 Jan 15;29(2):141-8. doi: 10.1016/0049-3848(83)90135-4.
Unfractionated heparin increased the binding of fibrinogen on ADP-treated platelets. The results varied according to both, the platelets of the donor and the kind of heparin preparation used. Beef lung heparin was more active than porcine intestinal mucosa heparin (p less than 0.02). A fraction of low molecular weight low sulfated heparin, did not significantly increase the binding of fibrinogen, except in one case for which the binding of fibrinogen to platelets was largely increased by standard heparin. On the contrary, pentosane polysulfate, a sulfated polysaccharide (of low molecular weight) significantly increased the binding of fibrinogen (p less than 0.01).
普通肝素增加了纤维蛋白原与二磷酸腺苷处理过的血小板的结合。结果因供体的血小板以及所用肝素制剂的种类而异。牛肺肝素比猪肠黏膜肝素更具活性（p小于0.02）。除了在一个案例中标准肝素使纤维蛋白原与血小板的结合大幅增加外，低分子量低硫酸化肝素的一个组分并未显著增加纤维蛋白原的结合。相反，低分子量硫酸化多糖戊聚糖多硫酸盐显著增加了纤维蛋白原的结合（p小于0.01）。
