血小板减少大鼠成纤维细胞和间皮细胞的正常有丝分裂反应性
Normal mitotic reactivity of fibroblasts and mesothelial cells in thrombocytopenic rat.
作者信息
Norrby K, Rammer L
出版信息
Virchows Arch B Cell Pathol Incl Mol Pathol. 1983;42(2):185-92. doi: 10.1007/BF02890381.
Mitotic reactivity following 48/80-induced mast-cell secretion was studied in the mesentery of rats made thrombocytopenic, 7 days following a single injection of melphalan. In spite of a low platelet count (7% of normal), the mitogenic reaction of the mesenteric fibroblasts and mesothelial cells was normal as judged by DNA-synthesis and mitotic index. The findings suggest that platelets and platelet-growth factors are not essential for the mast-cell-mediated mitogenic reaction of these two types of connective-tissue cells studied in vivo.
在单次注射美法仑7天后造成血小板减少的大鼠肠系膜中，研究了48/80诱导肥大细胞分泌后的有丝分裂反应。尽管血小板计数较低（为正常的7%），但通过DNA合成和有丝分裂指数判断，肠系膜成纤维细胞和间皮细胞的促有丝分裂反应是正常的。这些发现表明，血小板和血小板生长因子对于体内所研究的这两种结缔组织细胞的肥大细胞介导的促有丝分裂反应并非必不可少。
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