Nishijima S, Hosokawa H, Yanase K, Asada Y, Fujinami S
Acta Derm Venereol. 1983;63(2):173-5.
Multiple ulcers developed on the lower legs of a 67-year-old man suffering from macroglobulinemia. Histological and direct immunofluorescence studies on biopsy specimens taken from the lesions revealed dilation of capillaries, deposition of large quantities of IgM in the vessels, and deposition of C3 in the vessel walls. A marked increase in blood Clq binding immune complexes was also noted. These findings suggest immune complex-induced ulceration. The fact that IgM-type cryoglobulins were positive implies that cryoglobulins derived from macroglobulins may play an important causative role in ulceration.
一名患有巨球蛋白血症的67岁男性小腿出现多处溃疡。对取自病变部位的活检标本进行组织学和直接免疫荧光研究，结果显示毛细血管扩张、血管内大量IgM沉积以及血管壁C3沉积。还发现血液中Clq结合免疫复合物显著增加。这些发现提示免疫复合物诱导的溃疡形成。IgM型冷球蛋白呈阳性这一事实表明，源自巨球蛋白的冷球蛋白可能在溃疡形成中起重要的致病作用。
