Matsumoto J, Yasaka T, Ohya I, Ohtani H
Arch Intern Med. 1985 May;145(5):929-31.
Primary macroglobulinemia with acute renal failure developed in a 46-year-old man after administration of contrast medium (containing diatrizoate sodium and meglumine [Urografin]) for intravenous pyelography. On admission, the monoclonal protein peak could not be detected in serum by cellulose acetate electrophoresis, but the serial electrophoresis revealed a gradual increase in monoclonal protein peak, which later became two peaks. The serum of the patient contained the monoclonal small-molecule IgM kappa-chain protein with 13 to 14 Svedberg units in sedimentation constants, which is antigenetically the same as native IgM heavy chain. Although acute renal failure is extremely rare in primary macroglobulinemia, the small-molecule IgM seems to be one factor that induces acute renal failure.
一名46岁男性在静脉肾盂造影时使用了含泛影酸钠和葡甲胺（优维显）的造影剂后，发生了伴有急性肾衰竭的原发性巨球蛋白血症。入院时，醋酸纤维素电泳未能在血清中检测到单克隆蛋白峰，但连续电泳显示单克隆蛋白峰逐渐升高，随后变为两个峰。患者血清中含有沉降常数为13至14斯维德伯格单位的单克隆小分子IgM κ链蛋白，其抗原性与天然IgM重链相同。虽然急性肾衰竭在原发性巨球蛋白血症中极为罕见，但小分子IgM似乎是诱发急性肾衰竭的一个因素。
