Kino T, Oshima S
J Allergy Clin Immunol. 1978 Jan;61(1):10-6. doi: 10.1016/0091-6749(78)90467-0.
A high frequency of reaginic sensitivity to moth and butterfly extracts was shown in 66 randomly selected patients with bronchial asthma. Thirty-seven (56.1%) of these 66 patients showed positive intradermal reactions to 1:10,000 dilution of moth allergen and 34 patients (51.5%) had positive reactions to 1:10,000 butterfly allergen. These positive responses were as frequent as those to Candida or house dust which are recognized as the most commonly reactive allergens in Japan. Radioallergosorbent tests (RAST) showed that 20 of 66 sera were positive to moth and 22 sera were positive to butterfly, which indicates that about 1/3 of patients with bronchial asthma had specific IgE to moth and butterfly in the sera. Bronchial testing revealed that skin reaction-positive and RAST-positive patients were commonly provoked by specific allergen but skin reaction-negative and RAST-negative patients were not. These data suggest that moth and butterfly emanations could cause allergy-induced bronchial asthma in certain patients. Since moths are attracted readily to artificial lights and often fly into houses, these insects are especially suspect as important factors in extrinsic asthma.
在66例随机选择的支气管哮喘患者中，显示出对蛾和蝴蝶提取物的高频率反应素敏感性。这66例患者中有37例（56.1%）对1:10000稀释的蛾过敏原皮内反应呈阳性，34例患者（51.5%）对1:10000蝴蝶过敏原反应呈阳性。这些阳性反应与对念珠菌或屋尘的反应一样频繁，而念珠菌或屋尘在日本被认为是最常见的反应性过敏原。放射变应原吸附试验（RAST）显示，66份血清中有20份对蛾呈阳性，22份血清对蝴蝶呈阳性，这表明约1/3的支气管哮喘患者血清中存在针对蛾和蝴蝶的特异性IgE。支气管激发试验显示，皮肤反应阳性和RAST阳性的患者通常会被特异性过敏原激发，但皮肤反应阴性和RAST阴性的患者则不会。这些数据表明，蛾和蝴蝶的分泌物可能会在某些患者中引发过敏诱发的支气管哮喘。由于蛾很容易被人造光吸引，并且经常飞入房屋，这些昆虫特别被怀疑是外源性哮喘的重要因素。
