Tsakok F H, Koh S, Chua S E, Ratnam S S, Teisner B, Jones G R, Sinosich M, Grudzinskas J G
Br J Obstet Gynaecol. 1983 May;90(5):483-6. doi: 10.1111/j.1471-0528.1983.tb08949.x.
Circulating levels of four specific placental proteins, human chorionic gonadotrophin (hCG), Schwangerschafts protein 1 (SP1), placental protein 5 (PP5) and pregnancy-associated plasma protein A (PAPP-A), were measured in 31 patients with hydatidiform mole before treatment. Seven patients subsequently developed clinical choriocarcinoma and three of them had pulmonary metastases. The estimations of hCG, PP5 and PAPP-A levels were found to be of no value in the prediction of malignant sequelae. Levels of SP1 greater than or equal to 16.5 i.u./l were associated with a higher incidence of subsequent malignant disease (P less than 0.05), the risk being at least nine times greater in these patients. The predictive value of high levels of SP1 was 35%, the specificity 45.8% and sensitivity 100%.
在31例葡萄胎患者治疗前检测了四种特定胎盘蛋白，即人绒毛膜促性腺激素（hCG）、妊娠相关蛋白1（SP1）、胎盘蛋白5（PP5）和妊娠相关血浆蛋白A（PAPP-A）的循环水平。7例患者随后发展为临床绒毛膜癌，其中3例有肺转移。结果发现，hCG、PP5和PAPP-A水平的测定对预测恶性后遗症没有价值。SP1水平大于或等于16.5国际单位/升与随后发生恶性疾病的较高发生率相关（P<0.05），这些患者的风险至少高出9倍。高水平SP1的预测价值为35%，特异性为45.8%，敏感性为100%。
