Grbović L, Radmanović B Z
Br J Pharmacol. 1983 Apr;78(4):681-5. doi: 10.1111/j.1476-5381.1983.tb09420.x.
1 The effects of substance P (SP) on the responses of the guinea-pig isolated ileum to periarterial nerve stimulation were studied. Electrical stimulation (2-50 Hz) of mesenteric periarterial nerves resulted in contraction of preparations pretreated with guanethidine. The responses were abolished by atropine and morphine, but unaffected by hexamethonium. 2 SP in a high concentration (0.65 mumol) inhibited reversibly, by about 40%, the responses of the guinea-pig isolated ileum to periarterial nerve stimulation. 3 SP in a very low concentration (0.18 pmol) potentiated (by about 20%) the responses of the guinea-pig isolated ileum to periarterial nerve stimulation. 4 In the presence of low concentrations (0.06-0.32 pmol) of SP, morphine (2.65 mumol) produced less inhibition of the responses to periarterial nerve stimulation, and recovery from morphine inhibition of contraction was accelerated. 5 These results indicate that SP may act as a modulator on prejunctional acetylcholine release in the guinea-pig ileum.
1 研究了P物质（SP）对豚鼠离体回肠对动脉周围神经刺激反应的影响。肠系膜动脉周围神经的电刺激（2 - 50赫兹）导致用胍乙啶预处理的标本收缩。这些反应被阿托品和吗啡消除，但不受六甲铵影响。2 高浓度（0.65微摩尔）的SP可逆性地抑制豚鼠离体回肠对动脉周围神经刺激的反应约40%。3 极低浓度（0.18皮摩尔）的SP增强（约20%）豚鼠离体回肠对动脉周围神经刺激的反应。4 在低浓度（0.06 - 0.32皮摩尔）的SP存在下，吗啡（2.65微摩尔）对动脉周围神经刺激反应的抑制作用减弱，且从吗啡引起的收缩抑制中恢复加速。5 这些结果表明，SP可能作为豚鼠回肠节前乙酰胆碱释放的调节剂。
