神经肽Y对豚鼠离体回肠中辣椒素敏感感觉神经外周终末逆向激活所引起反应的接头前调制作用。
Prejunctional modulatory action of neuropeptide Y on responses due to antidromic activation of peripheral terminals of capsaicin-sensitive sensory nerves in the isolated guinea-pig ileum.
作者信息
Takaki M, Nakayama S
机构信息
Department of Physiology, Okayama University Medical School, Japan.
出版信息
Br J Pharmacol. 1991 Jun;103(2):1449-52. doi: 10.1111/j.1476-5381.1991.tb09809.x.
Abstract
- The effect of neuropeptide Y (NPY) on motor responses produced by activation of capsaicin-sensitive primary afferents in the guinea-pig isolated ileum was determined by use of capsaicin itself and electrical mesenteric nerve stimulation as stimuli. 2. NPY inhibited or suppressed the cholinergic contractile response produced by electrical mesenteric nerve stimulation while leaving the contractile response to a threshold concentration of capsaicin. 3. NPY had no effect on motor responses produced by a submaximal concentration of substance P, the putative endogenous mediator of the 'efferent' function of sensory fibres in this preparation. 4. It is concluded that NPY exerted a prejunctional inhibitory action on transmitter release from peripheral endings of capsaicin-sensitive nerves at interneuronal synapses.
摘要
- 通过使用辣椒素本身和电刺激肠系膜神经作为刺激，测定了神经肽Y（NPY）对豚鼠离体回肠中辣椒素敏感的初级传入神经激活所产生的运动反应的影响。2. NPY抑制或压制了电刺激肠系膜神经所产生的胆碱能收缩反应，而对阈值浓度辣椒素的收缩反应没有影响。3. NPY对该制剂中感觉纤维“传出”功能的假定内源性介质——次最大浓度的P物质所产生的运动反应没有影响。4. 得出的结论是，NPY在神经元间突触处对辣椒素敏感神经的外周末梢释放递质发挥了节前抑制作用。
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本文引用的文献
1
Neuropeptide Y (NPY)-like immunoreactivity in peripheral noradrenergic neurons and effects of NPY on sympathetic function.外周去甲肾上腺素能神经元中的神经肽Y（NPY）样免疫反应性及NPY对交感神经功能的影响。
Acta Physiol Scand. 1982 Dec;116(4):477-80. doi: 10.1111/j.1748-1716.1982.tb07171.x.
2
High levels of neuropeptide Y in peripheral noradrenergic neurons in various mammals including man.在包括人类在内的各种哺乳动物的外周去甲肾上腺素能神经元中，神经肽Y水平较高。
Neurosci Lett. 1983 Dec 2;42(2):167-72. doi: 10.1016/0304-3940(83)90401-9.
3
Occurrence and distribution of neuropeptide-Y-immunoreactive nerves in the respiratory tract and middle ear.呼吸道和中耳中神经肽Y免疫反应性神经的发生与分布
Cell Tissue Res. 1984;237(2):321-7. doi: 10.1007/BF00217151.
4
Distribution, pathways and reactions to drug treatment of nerves with neuropeptide Y- and pancreatic polypeptide-like immunoreactivity in the guinea-pig digestive tract.豚鼠消化道中具有神经肽Y和胰多肽样免疫反应性的神经的分布、通路及对药物治疗的反应
Cell Tissue Res. 1983;234(1):71-92. doi: 10.1007/BF00217403.
5
Nerve fibers in the gut and pancreas of the rat displaying neuropeptide-Y immunoreactivity. Intrinsic and extrinsic origin.大鼠肠道和胰腺中显示神经肽Y免疫反应性的神经纤维。内在和外在起源。
Cell Tissue Res. 1983;230(3):487-93. doi: 10.1007/BF00216194.
6
The influence of substance P on the response of guinea-pig isolated ileum to periarterial nerve stimulation.P物质对豚鼠离体回肠对动脉周围神经刺激反应的影响。
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Nature. 1980 Jul 10;286(5769):155-7. doi: 10.1038/286155a0.
8
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9
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Nature. 1974 Aug 2;250(465):430-1. doi: 10.1038/250430a0.
10
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