Papka R E, Matulionis D H
Cell Tissue Res. 1983;230(3):517-25. doi: 10.1007/BF00216198.
Location and distribution of nerve fibers immunoreactive to substance P were studied in the mouse olfactory mucosa. A moderately dense plexus of fibers is present at the interface of the olfactory epithelium and the connective tissue of the lamina propria. In addition, many immunoreactive nerve fibers are noted in close association with Bowman's glands and blood vessels in the lamina propria. However, such fibers were not observed in olfactory epithelium proper nor in the fila olfactoria. Substance-P-immunoreactivity is almost totally abolished by treatment of animals with capsaicin, an agent known to deplete substance P from primary sensory neurons. It is suggested that the substance-P-immunoreactive fibers are of sensory origin, with their perikarya most likely located in the trigeminal ganglia. Functionally, they might influence local blood flow and/or the secretion of Bowman's glands.
对小鼠嗅黏膜中对P物质免疫反应的神经纤维的位置和分布进行了研究。在嗅上皮与固有层结缔组织的界面处存在中等密度的纤维丛。此外，在固有层中，许多免疫反应性神经纤维与鲍曼腺和血管紧密相连。然而，在嗅上皮本身和嗅丝中未观察到此类纤维。用辣椒素处理动物后，P物质免疫反应几乎完全消失，辣椒素是一种已知能从初级感觉神经元中耗尽P物质的药物。提示P物质免疫反应性纤维起源于感觉神经，其胞体很可能位于三叉神经节。在功能上，它们可能影响局部血流和/或鲍曼腺的分泌。
