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针对乳酸脱氢酶B的单克隆抑制因子。I. 该因子与其靶细胞之间的相互作用机制。

Monoclonal suppressor factor specific for lactate dehydrogenase B. I. Mechanism of interaction between the factor and its target cells.

作者信息

Ikezawa Z, Baxevanis C N, Nonaka M, Abe R, Tada T, Nagy Z A, Klein J

出版信息

J Exp Med. 1983 Jun 1;157(6):1855-66. doi: 10.1084/jem.157.6.1855.

DOI:10.1084/jem.157.6.1855

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2187026/

Abstract

Hybridomas secreting a monoclonal T suppressor-effector factor (TseF) were produced by fusion of a lactate dehydrogenase B (LDHB)-specific long-term T suppressor-effector (Tse) cell line with the BW5147 thymoma. A short exposure (4 h) to TseF completely suppresses the antigen-specific and A-restricted proliferation of LDHB-primed Lyt-1+2- [possibly helper (Th)] cells. The action of TseF on Th cells, as that of the Tse cells themselves, is antigen-specific and A-restricted. The interaction of TseF with Th cells involves two binding events, of which one occurs via antigen bridge, and the other represents the recognition of a factor-derived Ak-like moiety by the anti-Ak receptor of Th cells. The Ak-like moiety of the TseF carries the determinants that serve as restriction elements for antigen recognition by Th cells, and additional determinants demonstrable by T cell-specific monoclonal "anti-Ak" antibodies, however, it lacks serologically detectable determinants of the B cell-derived A alpha A beta class II Mhc molecules.

摘要

通过将乳酸脱氢酶B（LDHB）特异性长期T抑制效应细胞系（Tse）与BW5147胸腺瘤细胞融合，产生了分泌单克隆T抑制效应因子（TseF）的杂交瘤。短时间暴露（4小时）于TseF可完全抑制经LDHB致敏的Lyt-1 + 2 - [可能是辅助性（Th）]细胞的抗原特异性和A限制性增殖。TseF对Th细胞的作用，如同Tse细胞自身的作用一样，是抗原特异性和A限制性的。TseF与Th细胞的相互作用涉及两个结合事件，其中一个通过抗原桥发生，另一个代表Th细胞的抗Ak受体对因子衍生的Ak样部分的识别。TseF的Ak样部分携带作为Th细胞抗原识别限制元件的决定簇，以及可由T细胞特异性单克隆“抗Ak”抗体证明的其他决定簇，然而，它缺乏B细胞衍生的AαAβ II类Mhc分子的血清学可检测决定簇。