去除同种异体反应性细胞的反应性T细胞会对来自无反应性品系的同种异体巨噬细胞所呈递的抗原产生反应。
Responder T cells depleted of alloreactive cells react to antigen presented on allogeneic macrophages from nonresponder strains.
作者信息
Ishii N, Baxevanis C N, Nagy Z A, Klein J
出版信息
J Exp Med. 1981 Sep 1;154(3):978-82. doi: 10.1084/jem.154.3.978.
Abstract
T cells from strains responder to the antigen poly(Glu40 Ala60) (GA) were depleted of alloreactive cells by bromo-deoxyuridine and light treatment, and were subsequently primed in vitro in GA presented by allogeneic macrophages from nonresponder strains. Antigen-specific secondary proliferative responses restricted by allogeneic Ia molecules of the macrophages were obtained in all strain combinations tested. These data indicate that Ir gene-controlled nonresponsiveness cannot be the result of a failure of antigen presentation.
摘要
来自对抗原聚（谷氨酸40 丙氨酸60）（GA）有反应的品系的T细胞，通过溴脱氧尿苷和光照处理去除了同种反应性细胞，随后在体外由来自无反应品系的同种异体巨噬细胞呈递的GA中进行致敏。在所有测试的品系组合中，均获得了受巨噬细胞同种异体Ia分子限制的抗原特异性二次增殖反应。这些数据表明，Ir基因控制的无反应性不可能是抗原呈递失败的结果。
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本文引用的文献
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