一种特异性单克隆T细胞因子对L-谷氨酸60-L-丙氨酸30-L-酪氨酸10抗体及T细胞增殖反应的抑制作用
Suppression of antibody and T cell proliferative responses to L-glutamic acid60-L-alanine30-L-tyrosine10 by a specific monoclonal T cell factor.
作者信息
Kapp J A, Araneo B A, Clevinger B L
出版信息
J Exp Med. 1980 Jul 1;152(1):235-40. doi: 10.1084/jem.152.1.235.
Abstract
The synthetic terpolymer L-glutamic acid60-L-alanine30-L-tyrosine10 (GAT) stimulates GAT-specific suppressor T cells in nonresponder mice. Extracts from these T cells contain a GAT-specific soluble T cell suppressor factor (GAT-TsF) that inhibits development of GAT-specific plaque-forming cell (PFC) responses by spleen cells from nonresponder mice stimulated with GAT complexed to methylated bovine serum albumin (GAT-MBSA). These extracts also contain a factor that inhibits development of GAT-specific proliferative responses by GAT-MBSA-primed, nonresponder lymph node T cells. Experiments reported in this manuscript show that a hybrid T cell line, produced by fusion of the AKR thymoma, BW5147, with spleen cells that contain GAT-specific suppressor T cells, produces a constitutive GAT-specific suppresor factor that functionally and serologically resembles GAT-TsF extracted from T cells. More importantly, both GAT-specific PFC and T cell proliferative responses are inhibited by this factor.
摘要
合成三元共聚物L-谷氨酸60-L-丙氨酸30-L-酪氨酸10（GAT）可刺激无反应小鼠体内GAT特异性抑制性T细胞。这些T细胞的提取物含有一种GAT特异性可溶性T细胞抑制因子（GAT-TsF），该因子可抑制无反应小鼠的脾细胞在与甲基化牛血清白蛋白复合的GAT（GAT-MBSA）刺激下产生GAT特异性空斑形成细胞（PFC）反应。这些提取物还含有一种因子，可抑制GAT-MBSA致敏的无反应淋巴结T细胞产生GAT特异性增殖反应。本手稿中报道的实验表明，由AKR胸腺瘤BW5147与含有GAT特异性抑制性T细胞的脾细胞融合产生的杂交T细胞系可产生一种组成型GAT特异性抑制因子，其在功能和血清学上类似于从T细胞中提取的GAT-TsF。更重要的是，该因子可抑制GAT特异性PFC和T细胞增殖反应。
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Suppression of antibody and T cell proliferative responses to L-glutamic acid60-L-alanine30-L-tyrosine10 by a specific monoclonal T cell factor.一种特异性单克隆T细胞因子对L-谷氨酸60-L-丙氨酸30-L-酪氨酸10抗体及T细胞增殖反应的抑制作用
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J Exp Med. 1973 Nov 1;138(5):1107-20. doi: 10.1084/jem.138.5.1107.
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Antibodies to major histocompatibility antigens produced by hybrid cell lines.杂交细胞系产生的针对主要组织相容性抗原的抗体。
Nature. 1977 Apr 7;266(5602):550-2. doi: 10.1038/266550a0.
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Immunosuppressive factors from lymphoid cells of nonresponder mice primed with L-glutamic acid60-L-alanine30-L-tyrosine10. IV. Lack of strain restrictions among allogeneic, nonresponder donors and recipients.用L-谷氨酸60-L-丙氨酸30-L-酪氨酸10致敏的无反应小鼠淋巴细胞产生的免疫抑制因子。IV. 同种异体无反应供体和受体之间不存在品系限制。
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Specific suppressive factors produced by hybridomas derived from the fusion of enriched suppressor T cells and a T lymphoma cell line.由富集的抑制性T细胞与一种T淋巴瘤细胞系融合产生的杂交瘤所产生的特异性抑制因子。
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T-cell lines producing antigen-specific suppressor factor.产生抗原特异性抑制因子的T细胞系
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