Barontini F, Sitá D
J Neurol. 1983;229(1):33-44. doi: 10.1007/BF00313494.
Fisher's syndrome was studied in six patients, one of whom was an 11-year-old girl, and the nosological position of this neuro-ophthalmological disorder was reviewed. The clinical features of the ophthalmoplegia in these cases were reported as secondary to a transient inflammatory lesion in the mid-brain; this was demonstrated in one of the cases by an enhancing area on CT scan. This mid-brain localization could explain not only the classical Fisher's triad but also many variations of the syndrome. The overlap of our cases of Fisher's syndrome with so-called brain-stem encephalitis of Bickerstaff has been emphasized. Many cases of Fisher's syndrome could therefore correspond to an inflammatory process at brain-stem level with or without nerve-root involvement. Clinical and neurophysiological findings show, however, that there is peripheral damage in some cases, so that a neutral attitude needs to be maintained on the nosological position of Fisher's syndrome.
对6例Fisher综合征患者进行了研究，其中1例为11岁女孩，并对这种神经眼科疾病的病种归属进行了回顾。这些病例中眼肌麻痹的临床特征被报告为继发于中脑的短暂性炎性病变；其中1例通过CT扫描上的强化区域得以证实。这种中脑定位不仅可以解释典型的Fisher三联征，还能解释该综合征的许多变异情况。强调了我们的Fisher综合征病例与所谓的Bickerstaff脑干脑炎存在重叠。因此，许多Fisher综合征病例可能对应于脑干水平的炎性过程，伴或不伴有神经根受累。然而，临床和神经生理学发现表明，在某些病例中存在周围神经损伤，因此对于Fisher综合征的病种归属需要保持中立态度。
