Fasmer O B, Berge O G, Hole K
Neuropharmacology. 1983 Apr;22(4):485-7. doi: 10.1016/0028-3908(83)90167-3.
Intrathecal injection of 5-hydroxytryptamine (5-HT) or of substance P in mice elicited a behavioural syndrome consisting of reciprocal hindlimb scratching and biting or licking, directed towards the caudal parts of the body. 5-Hydroxtryptamine elicited more scratching than did substance P, which in turn caused a greater number of biting or licking responses. The 5-HT-induced responses were mimicked by 5,6-dihydroxytryptamine and inhibited by the 5-HT receptor blocker metergoline. The present findings indicate that 5-HT, injected intrathecally, may have similar effects as substance P in stimulating sensory pathways in the spinal cord.
向小鼠鞘内注射5-羟色胺（5-HT）或P物质会引发一种行为综合征，表现为相互的后肢抓挠以及针对身体尾部的啃咬或舔舐。5-羟色胺引发的抓挠比P物质更多，而P物质反过来会引起更多的啃咬或舔舐反应。5,6-二羟基色胺可模拟5-HT诱导的反应，5-HT受体阻滞剂美替拉酮可抑制该反应。目前的研究结果表明，鞘内注射5-HT在刺激脊髓感觉通路方面可能具有与P物质相似的作用。
