P物质类似物对小鼠鞘内注射N-甲基-D-天冬氨酸诱导的抓挠、啃咬和舔舐反应的影响。
The effects of substance P analogues on the scratching, biting and licking response induced by intrathecal injection of N-methyl-D-aspartate in mice.
作者信息
Sakurada T, Manome Y, Tan-No K, Sakurada S, Kisara K
机构信息
Department of Pharmacology, Tohoku College of Pharmacy, Aoba-ku, Japan.
出版信息
Br J Pharmacol. 1990 Oct;101(2):307-10. doi: 10.1111/j.1476-5381.1990.tb12706.x.
Abstract
- Intrathecal (i.t.) administration of N-methyl-D-aspartate (NMDA) elicited a dose-dependent behavioural response consisting of licking, biting and scratching in mice. 2. Repeated i.t. injections of 0.4 nmol NMDA, at 5 min intervals, resulted in the rapid development of desensitization to this NMDA-induced behavioural phenomenon. 3. The NMDA-induced response was dose-dependently inhibited by the simultaneous injection of a selective NMDA-receptor antagonist, D-2-amino-5-phosphonovaleric acid. 4. The substance P (SP) analogues [D-Pro2, D-Trp7,9] SP and [D-Arg1, D-Trp7,9, Leu11] SP (spantide) inhibited NMDA-induced behavioural responses in a dose-dependent manner. However, [D-Phe7, D-His9] SP (6-11), a SP analogue selective for neurokinin1 (NK1) receptors, failed to inhibit NMDA-induced responses even at a dose of 4.0 nmol. 5. These results indicate that NMDA-induced behavioural responses are mainly mediated through NMDA receptors without affecting NK1 receptors in the spinal cord.
摘要
- 鞘内注射N-甲基-D-天冬氨酸（NMDA）可在小鼠中引发一种剂量依赖性行为反应，包括舔舐、撕咬和抓挠。2. 以5分钟的间隔重复鞘内注射0.4纳摩尔NMDA，会导致对这种NMDA诱导的行为现象迅速产生脱敏。3. 同时注射选择性NMDA受体拮抗剂D-2-氨基-5-磷酸缬氨酸可剂量依赖性地抑制NMDA诱导的反应。4. P物质（SP）类似物[D-脯氨酸2，D-色氨酸7,9] SP和[D-精氨酸1，D-色氨酸7,9，亮氨酸11] SP（spantide）以剂量依赖性方式抑制NMDA诱导的行为反应。然而，对神经激肽1（NK1）受体具有选择性的SP类似物[D-苯丙氨酸7，D-组氨酸9] SP（6-11）即使在4.0纳摩尔的剂量下也未能抑制NMDA诱导的反应。5. 这些结果表明，NMDA诱导的行为反应主要通过NMDA受体介导，而不影响脊髓中的NK1受体。
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