• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
The effects of substance P analogues on the scratching, biting and licking response induced by intrathecal injection of N-methyl-D-aspartate in mice.P物质类似物对小鼠鞘内注射N-甲基-D-天冬氨酸诱导的抓挠、啃咬和舔舐反应的影响。
Br J Pharmacol. 1990 Oct;101(2):307-10. doi: 10.1111/j.1476-5381.1990.tb12706.x.
2
Substance P analogues containing D-histidine antagonize the behavioural effects of intrathecally co-administered substance P in mice.含有D-组氨酸的P物质类似物可拮抗小鼠鞘内共同给予P物质的行为效应。
Eur J Pharmacol. 1989 Dec 19;174(2-3):153-60. doi: 10.1016/0014-2999(89)90307-5.
3
Nociceptin-induced scratching, biting and licking in mice: involvement of spinal NK1 receptors.孤啡肽诱导小鼠抓挠、撕咬和舔舐行为：脊髓神经激肽-1受体的作用
Br J Pharmacol. 1999 Aug;127(7):1712-8. doi: 10.1038/sj.bjp.0702698.
4
Differential effects of substance P analogs on neurokinin 1 receptor agonists in the mouse spinal cord.P物质类似物对小鼠脊髓中神经激肽1受体激动剂的不同作用。
J Pharmacol Exp Ther. 1991 Oct;259(1):205-10.
5
Comparison of antagonistic effects of sendide and CP-96,345 on a spinally mediated behavioural response in mice.森地德与CP-96,345对小鼠脊髓介导行为反应的拮抗作用比较。
Eur J Pharmacol. 1994 Aug 11;261(1-2):85-90. doi: 10.1016/0014-2999(94)90304-2.
6
Naloxone-reversible effect of spantide on the spinally mediated behavioural response induced by neurokinin-2 and -3 receptor agonists.
Naunyn Schmiedebergs Arch Pharmacol. 1992 Jul;346(1):69-75. doi: 10.1007/BF00167573.
7
Involvement of tachykinin NK1 receptors in nociceptin-induced hyperalgesia in mice.速激肽NK1受体在孤啡肽诱导的小鼠痛觉过敏中的作用。
Brain Res. 1999 Sep 11;841(1-2):85-92. doi: 10.1016/s0006-8993(99)01800-4.
8
Opioid activity of sendide, a tachykinin NK1 receptor antagonist.速激肽NK1受体拮抗剂仙地肽的阿片样物质活性。
Eur J Pharmacol. 1999 Mar 26;369(3):261-6. doi: 10.1016/s0014-2999(99)00078-3.
9
Intrathecally administered big dynorphin, a prodynorphin-derived peptide, produces nociceptive behavior through an N-methyl-D-aspartate receptor mechanism.鞘内注射大强啡肽（一种源自前强啡肽的肽）通过N-甲基-D-天冬氨酸受体机制产生伤害感受行为。
Brain Res. 2002 Oct 11;952(1):7-14. doi: 10.1016/s0006-8993(02)03180-3.
10
Pharmacological characterisation of NK1 receptor antagonist, [D-Trp7]sendide, on behaviour elicited by substance P in the mouse.NK1受体拮抗剂[D-色氨酸7]山德肽对P物质诱发小鼠行为的药理学特性研究
Naunyn Schmiedebergs Arch Pharmacol. 1994 Oct;350(4):387-92. doi: 10.1007/BF00178956.

引用本文的文献

1
Effect of Radiofrequency Electromagnetic Fields on Thermal Sensitivity in the Rat.射频电磁场对大鼠热敏感性的影响。
Int J Environ Res Public Health. 2020 Oct 18;17(20):7563. doi: 10.3390/ijerph17207563.
2
Effects of Intraperitoneal N-methyl-D-aspartate (NMDA) Administration on Nociceptive/Repetitive Behaviors in Juvenile Mice.腹腔注射N-甲基-D-天冬氨酸（NMDA）对幼年小鼠伤害性/重复性行为的影响。
Biomol Ther (Seoul). 2019 Mar 1;27(2):168-177. doi: 10.4062/biomolther.2018.230.
3
Peripheral NMDA Receptor/NO System Blockage Inhibits Itch Responses Induced by Chloroquine in Mice.外周N-甲基-D-天冬氨酸受体/一氧化氮系统阻断抑制氯喹诱导的小鼠瘙痒反应。
Acta Derm Venereol. 2017 May 8;97(5):571-577. doi: 10.2340/00015555-2617.
4
Mechanisms involved in the antinociception induced by systemic administration of guanosine in mice.系统给予鸟苷在小鼠体内诱导镇痛作用的相关机制。
Br J Pharmacol. 2010 Mar;159(6):1247-63. doi: 10.1111/j.1476-5381.2009.00597.x. Epub 2010 Feb 2.
5
Neuromedin U receptor 2-deficient mice display differential responses in sensory perception, stress, and feeding.神经介素U受体2缺陷型小鼠在感觉知觉、应激和进食方面表现出不同的反应。
Mol Cell Biol. 2006 Dec;26(24):9352-63. doi: 10.1128/MCB.01148-06. Epub 2006 Oct 9.
6
Nociceptin-induced scratching, biting and licking in mice: involvement of spinal NK1 receptors.孤啡肽诱导小鼠抓挠、撕咬和舔舐行为：脊髓神经激肽-1受体的作用
Br J Pharmacol. 1999 Aug;127(7):1712-8. doi: 10.1038/sj.bjp.0702698.
7
5-HT4 receptor-mediated modulation of 5-HT release in the rat hippocampus in vivo.5-羟色胺4受体介导的大鼠海马体内5-羟色胺释放的调节
Br J Pharmacol. 1996 Apr;117(7):1475-80. doi: 10.1111/j.1476-5381.1996.tb15309.x.
8
Functional characterization of a 5-HT3 receptor which modulates the release of 5-HT in the guinea-pig brain.一种调节豚鼠脑内5-羟色胺释放的5-羟色胺3型受体的功能特性
Br J Pharmacol. 1993 Jan;108(1):13-22. doi: 10.1111/j.1476-5381.1993.tb13433.x.
9
Inhibitory effects of salmon calcitonin on the tail-biting and scratching behavior induced by substance P and three excitatory amino acids.鲑鱼降钙素对P物质及三种兴奋性氨基酸诱导的咬尾和抓挠行为的抑制作用。
J Neural Transm Gen Sect. 1994;96(2):125-33. doi: 10.1007/BF01277934.
10
Naloxone-reversible effect of spantide on the spinally mediated behavioural response induced by neurokinin-2 and -3 receptor agonists.
Naunyn Schmiedebergs Arch Pharmacol. 1992 Jul;346(1):69-75. doi: 10.1007/BF00167573.

本文引用的文献

1
Intrathecal morphine in mice: a new technique.小鼠鞘内注射吗啡：一项新技术。
Eur J Pharmacol. 1980 Oct 17;67(2-3):313-6. doi: 10.1016/0014-2999(80)90515-4.
2
The dissociative anaesthetics, ketamine and phencyclidine, selectively reduce excitation of central mammalian neurones by N-methyl-aspartate.分离麻醉药氯胺酮和苯环己哌啶可选择性降低N-甲基天冬氨酸对中枢哺乳动物神经元的兴奋作用。
Br J Pharmacol. 1983 Jun;79(2):565-75. doi: 10.1111/j.1476-5381.1983.tb11031.x.
3
On the nature of the receptors for various excitatory amino acids in the mammalian central nervous system.
Adv Biochem Psychopharmacol. 1981;27:253-62.
4
Tachykinin-like central activity of neuromedin K in mice.神经介素K在小鼠体内的速激肽样中枢活性。
Eur J Pharmacol. 1984 Aug 17;103(3-4):355-7. doi: 10.1016/0014-2999(84)90499-0.
5
Hyperalgesia produced by intrathecal substance P and related peptides: desensitization and cross desensitization.鞘内注射P物质及相关肽所产生的痛觉过敏：脱敏和交叉脱敏
Br J Pharmacol. 1984 Jun;82(2):381-8. doi: 10.1111/j.1476-5381.1984.tb10773.x.
6
Behavioural responses induced by intrathecal injection of 5-hydroxytryptamine in mice are inhibited by a substance P antagonist, D-Pro2, D-Trp7,9-substance P.
Neuropharmacology. 1983 Dec;22(12A):1397-400. doi: 10.1016/0028-3908(83)90230-7.
7
Neural actions of several substance P antagonists in the rat spinal cord.几种P物质拮抗剂在大鼠脊髓中的神经作用。
Neurosci Lett. 1983 Jun 30;37(3):279-83. doi: 10.1016/0304-3940(83)90444-5.
8
The behavioural effects of intrathecally administered [D-PRO2, D-TRP7,9]-substance P, an analogue with presumed antagonist actions, in the rat.
Neuropharmacology. 1983 Feb;22(2):173-6. doi: 10.1016/0028-3908(83)90005-9.
9
Intrathecal opioids block a spinal action of substance P in mice: functional importance of both mu- and delta-receptors.鞘内注射阿片类药物可阻断小鼠体内P物质的脊髓作用：μ受体和δ受体的功能重要性
Eur J Pharmacol. 1982 Dec 17;86(1):95-8. doi: 10.1016/0014-2999(82)90403-4.
10
Substance P reduces tail-flick latency: implications for chronic pain syndromes.
Pain. 1982 Oct;14(2):155-167. doi: 10.1016/0304-3959(82)90096-3.

P物质类似物对小鼠鞘内注射N-甲基-D-天冬氨酸诱导的抓挠、啃咬和舔舐反应的影响。

The effects of substance P analogues on the scratching, biting and licking response induced by intrathecal injection of N-methyl-D-aspartate in mice.

作者信息

Sakurada T, Manome Y, Tan-No K, Sakurada S, Kisara K

机构信息

Department of Pharmacology, Tohoku College of Pharmacy, Aoba-ku, Japan.

出版信息

Br J Pharmacol. 1990 Oct;101(2):307-10. doi: 10.1111/j.1476-5381.1990.tb12706.x.

DOI:10.1111/j.1476-5381.1990.tb12706.x
PMID:1701675
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1917692/
Abstract
  1. Intrathecal (i.t.) administration of N-methyl-D-aspartate (NMDA) elicited a dose-dependent behavioural response consisting of licking, biting and scratching in mice. 2. Repeated i.t. injections of 0.4 nmol NMDA, at 5 min intervals, resulted in the rapid development of desensitization to this NMDA-induced behavioural phenomenon. 3. The NMDA-induced response was dose-dependently inhibited by the simultaneous injection of a selective NMDA-receptor antagonist, D-2-amino-5-phosphonovaleric acid. 4. The substance P (SP) analogues [D-Pro2, D-Trp7,9] SP and [D-Arg1, D-Trp7,9, Leu11] SP (spantide) inhibited NMDA-induced behavioural responses in a dose-dependent manner. However, [D-Phe7, D-His9] SP (6-11), a SP analogue selective for neurokinin1 (NK1) receptors, failed to inhibit NMDA-induced responses even at a dose of 4.0 nmol. 5. These results indicate that NMDA-induced behavioural responses are mainly mediated through NMDA receptors without affecting NK1 receptors in the spinal cord.
摘要
  1. 鞘内注射N-甲基-D-天冬氨酸（NMDA）可在小鼠中引发一种剂量依赖性行为反应，包括舔舐、撕咬和抓挠。2. 以5分钟的间隔重复鞘内注射0.4纳摩尔NMDA，会导致对这种NMDA诱导的行为现象迅速产生脱敏。3. 同时注射选择性NMDA受体拮抗剂D-2-氨基-5-磷酸缬氨酸可剂量依赖性地抑制NMDA诱导的反应。4. P物质（SP）类似物[D-脯氨酸2，D-色氨酸7,9] SP和[D-精氨酸1，D-色氨酸7,9，亮氨酸11] SP（spantide）以剂量依赖性方式抑制NMDA诱导的行为反应。然而，对神经激肽1（NK1）受体具有选择性的SP类似物[D-苯丙氨酸7，D-组氨酸9] SP（6-11）即使在4.0纳摩尔的剂量下也未能抑制NMDA诱导的反应。5. 这些结果表明，NMDA诱导的行为反应主要通过NMDA受体介导，而不影响脊髓中的NK1受体。