Hopf H C, Maurer K
Electroencephalogr Clin Neurophysiol. 1983 Jul;56(1):31-7. doi: 10.1016/0013-4694(83)90004-4.
Early auditory evoked potentials (EAEPs) were recorded in a series of 71 consecutively examined patients suffering from clinically definite or probable multiple sclerosis (MS). Wave I abnormalities, i.e., delayed latency, with or without reduced amplitude, were observed in 15 such patients and were interpreted as due to MS in 8 of them. As EAEP wave I is identical with the potential N1 in electrocochleography and corresponds to activity of the most distal part of the acoustic nerve or the spiral ganglion, it is concluded that the peripheral part of the acoustic nerve is involved in about 10% of MS patients. In two cases normalization of initially delayed wave I latencies were demonstrated during follow-up recording. The pattern of a late wave I but normal hearing in 3 patients is interpreted in terms of a desynchronized compound nerve activity with fully preserved conductivity, segmental demyelination of a considerable number of acoustic nerve fibres being the most likely cause.
对71例连续接受检查的临床确诊或疑似多发性硬化症（MS）患者记录了早期听觉诱发电位（EAEP）。在15例此类患者中观察到I波异常，即潜伏期延长，伴或不伴波幅降低，其中8例被解释为MS所致。由于EAEP的I波与耳蜗电图中的N1电位相同，且对应于听神经最远端部分或螺旋神经节的活动，因此得出结论，约10%的MS患者听神经的外周部分受累。在2例患者的随访记录中，最初延迟的I波潜伏期恢复正常。3例患者出现I波延迟但听力正常的情况，被解释为复合神经活动不同步但传导性完全保留，相当数量的听神经纤维节段性脱髓鞘最有可能是其原因。
