del Palacio Hernanz A, Fereres J, Larregla Garraus S, Rodriguez-Noriega A, Sanz Sanz F
J Hosp Infect. 1983 Mar;4(1):45-9. doi: 10.1016/0195-6701(83)90064-6.
Three patients suffering from acute leukaemia were treated with cytotoxic agents and broad-spectrum antibiotics and received blood transfusion and nasal packing for severe epistaxis. All developed necrosis of nasal and facial tissues, with facial swelling an oedema; two biopsies showed typical phycomycete mycelium, and Rhizomucor pusillus was grown from one biopsy. Air and surfaces in the unit and the air intake and ducting were all heavily colonized by Rh. pusillus and other phycomycetes. It is suggested that Rh. pusillus spores from the air invaded the tissues in the conditions promoted by the nasal packing in these patients with impaired defences.
三名急性白血病患者接受了细胞毒性药物和广谱抗生素治疗，并因严重鼻出血接受了输血和鼻腔填塞。所有患者均出现鼻和面部组织坏死，伴有面部肿胀和水肿；两次活检显示有典型的藻菌纲菌丝体，一次活检培养出了微小根毛霉。病房内的空气、表面以及进气口和管道均被微小根毛霉和其他藻菌纲真菌严重定植。提示在这些防御功能受损的患者中，空气中的微小根毛霉孢子在鼻腔填塞所促成的条件下侵入了组织。
