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儿童在使用博纳吐单抗进行抗白血病治疗期间发生的暴发性毛霉菌病：一例病例报告及文献复习

Fulminant mucormycosis during anti-leukemic treatment with blinatumomab in a child: A case report and review of the literature.

作者信息

Schober Sarah, Cabanillas Stanchi Karin Melanie, Riecker Anna, Pfeiffer Matthias, Tsiflikas Ilias, Wiegand Gesa, Quintanilla-Martinez Leticia, Haen Susanne, Ebinger Martin, Lang Peter, Handgretinger Rupert, Döring Michaela

机构信息

University Children's Hospital Tuebingen, Department I - General Pediatrics, Hematology/Oncology, Hoppe-Seyler-Str.1, 72076, Tuebingen, Germany.

Department of Diagnostic and Interventional Radiology, University Hospital Tuebingen, Hoppe-Seyler-Str. 3, 72076, Tuebingen, Germany.

出版信息

Med Mycol Case Rep. 2020 Dec 29;32:4-9. doi: 10.1016/j.mmcr.2020.12.002. eCollection 2021 Jun.

DOI:10.1016/j.mmcr.2020.12.002
PMID:33489743
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7806943/
Abstract

This is the first published case report of a child with acute lymphatic leukemia developing a fatal mucormycosis during blinatumomab treatment. The patient showed multiple, systemic thromboembolic lesions with ischemia, bleeding and infarction in almost all organs. The child succumbed to increased brain pressure resulting in cerebral herniation. This case particularly illustrates the fulminant progression and huge challenges of diagnosing and treating mucormycosis in children with hemato-oncological diseases during treatment with targeted therapeutic antibodies (blinatumomab).

摘要

这是首例关于一名急性淋巴细胞白血病患儿在接受博纳吐单抗治疗期间发生致命性毛霉菌病的病例报告。该患者几乎所有器官均出现多处全身性血栓栓塞性病变，并伴有缺血、出血和梗死。患儿因颅内压升高导致脑疝而死亡。该病例特别说明了在使用靶向治疗抗体（博纳吐单抗）治疗血液肿瘤疾病的儿童中，毛霉菌病的暴发性进展以及诊断和治疗所面临的巨大挑战。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc1b/7806943/b00677cbd5f5/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc1b/7806943/d3d4930d4682/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc1b/7806943/64746512705a/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc1b/7806943/3bfb0bad4e09/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc1b/7806943/fcf3ad171058/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc1b/7806943/b00677cbd5f5/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc1b/7806943/d3d4930d4682/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc1b/7806943/64746512705a/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc1b/7806943/3bfb0bad4e09/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc1b/7806943/fcf3ad171058/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc1b/7806943/b00677cbd5f5/gr5.jpg

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Systemic trichosporonosis mimicking disseminated varicella zoster viral infection during blinatumomab therapy.在blinatumomab治疗期间，系统性毛孢子菌病酷似播散性水痘带状疱疹病毒感染。
Ann Hematol. 2018 Feb;97(2):371-373. doi: 10.1007/s00277-017-3153-0. Epub 2017 Oct 14.
3
Invasive mucormycosis in children: an epidemiologic study in European and non-European countries based on two registries.
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J Assoc Med Microbiol Infect Dis Can. 2023 Mar 1;8(1):105-110. doi: 10.3138/jammi-2022-0020. eCollection 2023 Mar.
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Infectious Complications of Targeted Therapies in Children with Leukemias and Lymphomas.白血病和淋巴瘤患儿靶向治疗的感染并发症
Cancers (Basel). 2022 Oct 14;14(20):5022. doi: 10.3390/cancers14205022.
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The pharmacology of blinatumomab: state of the art on pharmacodynamics, pharmacokinetics, adverse drug reactions and evaluation in clinical trials.blinatumomab 的药理学：药效学、药代动力学、药物不良反应及临床试验评估的最新进展。
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