药物设计与开发。现实评估。

Drug design and development. A realistic appraisal.

作者信息

Burger A

出版信息

J Med Chem. 1978 Jan;21(1):1-4. doi: 10.1021/jm00199a001.

PMID:619137

Abstract

The discovery of new biologically-therapeutically active structures continues to depend on screening and on isolated observations of unexpected drug metabolites and drug activities. The selection of therapeutically improved and useful chemicals requires molecular modification. Refinements in intuitive and physiochemical methodology can provide shortcuts in random choices and permit extrapolations of some facets of activity with a variable degree of accuracy. The final decisions concerning the usefulness of a drug remain in the domain of experimental and clinical pharmacology.

摘要

新的生物治疗活性结构的发现仍然依赖于筛选以及对意外药物代谢产物和药物活性的孤立观察。选择经过治疗改进且有用的化学物质需要进行分子修饰。直观和物理化学方法的改进可以在随机选择中提供捷径，并允许以不同程度的准确性推断活性的某些方面。关于一种药物有用性的最终决定仍属于实验和临床药理学的范畴。