Bogdanikowa B, Myśliwiec M, Bielawiec M, Kiersnowska-Rogowska B
Folia Haematol Int Mag Klin Morphol Blutforsch. 1976;103(2):248-51.
The influence of azathioprine on human platelets was studied in vitro. Azathioprine in a final concentration of 10(-4) M caused significant inhibition of spontaneous sedimentation and aggregation of platelets, but did not effect platelet adhesiveness or resistance to freezing and thawing. The influence of azathioprine is probably due to thioimidazole, this last being a potent stimulating agent of phosphodiesterase activity, involved in the metabolism of cyclic AMP to 5' AMP. These observations indicate that the widely used platelet function assays could be influenced by drugs. The current therapy should therefore be taken into account when the results of the tests are evaluated for clinical purposes.
在体外研究了硫唑嘌呤对人血小板的影响。终浓度为10（-4）M的硫唑嘌呤可显著抑制血小板的自发沉降和聚集，但不影响血小板的黏附性或对冻融的耐受性。硫唑嘌呤的影响可能归因于硫代咪唑，后者是磷酸二酯酶活性的强效刺激剂，参与环磷酸腺苷代谢为5'-腺苷酸。这些观察结果表明，广泛使用的血小板功能检测可能会受到药物的影响。因此，在为临床目的评估检测结果时，应考虑当前的治疗情况。
