Effect of cytostatics on some platelet functions in vitro. VI. Vinblastine.

The influence of vinblastine upon principal functions of blood platelets in vitro (adhesion, aggregation, platelet release reaction, membrane stabilization) has been followed using an extended system of laboratory examinations. The authors have found that the concentration of vinblastine which is higher than the average therapeutic dose (10(-5)M) inhibits the functional ability of platelets so that it may cause a thrombopatic disorder.