细胞抑制剂对体外某些血小板功能的影响。VI. 长春碱。
Effect of cytostatics on some platelet functions in vitro. VI. Vinblastine.
作者信息
Parízek M, Kubisz P
出版信息
Neoplasma. 1978;25(5):625-9.
PMID:740063
Abstract
The influence of vinblastine upon principal functions of blood platelets in vitro (adhesion, aggregation, platelet release reaction, membrane stabilization) has been followed using an extended system of laboratory examinations. The authors have found that the concentration of vinblastine which is higher than the average therapeutic dose (10(-5)M) inhibits the functional ability of platelets so that it may cause a thrombopatic disorder.
摘要
利用一套扩展的实验室检测系统，研究了长春碱对体外血小板主要功能（黏附、聚集、血小板释放反应、膜稳定）的影响。作者发现，高于平均治疗剂量（10⁻⁵M）的长春碱浓度会抑制血小板的功能能力，从而可能导致血小板生成紊乱。
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