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一种抗乙酰胆碱受体单克隆抗体与卵黄高磷蛋白发生交叉反应。

An anti-acetylcholine receptor monoclonal antibody cross-reacts with phosvitin.

作者信息

Pizzighella S, Gordon A S, Souroujon M C, Mochly-Rosen D, Sharp A, Fuchs S

出版信息

FEBS Lett. 1983 Aug 8;159(1-2):246-50. doi: 10.1016/0014-5793(83)80456-6.

DOI:10.1016/0014-5793(83)80456-6
PMID:6192017
Abstract

Rabbit and mouse anti-Torpedo acetylcholine receptor antibodies cross-reacted partially with the highly phosphorylated protein, phosvitin. We have selected an anti-Torpedo acetylcholine receptor monoclonal antibody which binds specifically to phosvitin; this binding is inhibited by acetylcholine receptor. These findings suggest that a phosphorylated amino acid residue may be a part of the determinant on the acetylcholine receptor recognized by this monoclonal antibody.

摘要

兔和小鼠抗电鳐乙酰胆碱受体抗体与高度磷酸化的蛋白质——卵黄高磷蛋白发生部分交叉反应。我们筛选出了一种抗电鳐乙酰胆碱受体单克隆抗体，它能特异性结合卵黄高磷蛋白；这种结合可被乙酰胆碱受体抑制。这些发现表明，一个磷酸化的氨基酸残基可能是该单克隆抗体所识别的乙酰胆碱受体决定簇的一部分。

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Analysis of acetylcholine receptor phosphorylation sites using antibodies to synthetic peptides and monoclonal antibodies.使用针对合成肽的抗体和单克隆抗体分析乙酰胆碱受体磷酸化位点。
EMBO J. 1986 Dec 1;5(12):3175-8. doi: 10.1002/j.1460-2075.1986.tb04626.x.
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A monoclonal antibody to the phosphorylated form of phenylalanine hydroxylase. Definition of the phosphopeptide epitope.一种针对苯丙氨酸羟化酶磷酸化形式的单克隆抗体。磷酸肽表位的定义。
Biochem J. 1987 Jun 15;244(3):625-31. doi: 10.1042/bj2440625.

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