O'Neill J J
Fundam Appl Toxicol. 1981 Mar-Apr;1(2):154-60.
The presence in the nervous tissue of extremely potent peptides arises from the enzymatic degradation of larger molecular weight proteins. These smaller units are thought to exert modulatory actions on known transmitters. Their short half-life when injected is due to the degradative action of specific EXO and ENDOPEPTIDASES. It is suggested from the meager evidence available that organophosphates may adversely affect the processes of formation and/or degradation to account for many of the adverse effects of organophosphate anticholinesterases which cannot be attributed to acetylcholine accumulation.
极具活性的肽类物质在神经组织中的存在源于较大分子量蛋白质的酶促降解。这些较小的单位被认为对已知的神经递质发挥调节作用。注射时它们的半衰期较短是由于特定外肽酶和内肽酶的降解作用。从现有少量证据来看，有机磷酸酯可能对形成和/或降解过程产生不利影响，以此来解释有机磷酸酯抗胆碱酯酶的许多无法归因于乙酰胆碱积累的不良反应。
