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钙离子拮抗剂硝苯地平对大鼠腹腔肥大细胞组胺释放的抑制作用。

Inhibitory effect of the CA2+ antagonist nifedipine on histamine release from rat peritoneal mast cells.

作者信息

Tanizaki Y, Komagoe H, Sudo M, Ohtani J, Kimura I, Akagi K, Townley R G

出版信息

Acta Med Okayama. 1983 Jun;37(3):207-11. doi: 10.18926/AMO/32436.

DOI:10.18926/AMO/32436
PMID:6192686
Abstract

45Ca uptake and histamine release was examined in mast cells from rats sensitized with ovalbumin and Bordetella Bertussis as an adjuvant. The uptake of 45Ca by the mast cells was significantly increased by stimulation with ovalbumin as was the release of histamine from the mast cells. Nifedipine, a calcium antagonist, inhibited the increase in both 45Ca uptake and histamine release stimulated by ovalbumin, though the effect on 45Ca uptake was stronger than that on histamine release.

摘要

以卵清蛋白致敏并用百日咳博德特氏菌作为佐剂的大鼠肥大细胞,对其45Ca摄取和组胺释放进行了检测。用卵清蛋白刺激后,肥大细胞对45Ca的摄取以及肥大细胞中组胺的释放均显著增加。钙拮抗剂硝苯地平抑制了由卵清蛋白刺激引起的45Ca摄取和组胺释放的增加,尽管其对45Ca摄取的影响比对组胺释放的影响更强。

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Inhibitory effect of the CA2+ antagonist nifedipine on histamine release from rat peritoneal mast cells.钙离子拮抗剂硝苯地平对大鼠腹腔肥大细胞组胺释放的抑制作用。
Acta Med Okayama. 1983 Jun;37(3):207-11. doi: 10.18926/AMO/32436.
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Eur J Pharmacol. 1982 Nov 19;85(2):155-61. doi: 10.1016/0014-2999(82)90460-5.

引用本文的文献

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Heterogeneity of calcium channels in mast cells and basophils and the possible relevance to pathophysiology of lung diseases: a review.肥大细胞和嗜碱性粒细胞中钙通道的异质性及其与肺部疾病病理生理学的可能关联:综述
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