针对胎儿主要组织相容性抗原的免疫反应中的性别相关差异。II. 雌性IgG1与H-2K编码的同种异体抗原的关联。

Sex-associated differences in the immune response against fetal major histocompatibility antigens. II. Association of the female IgG1 with H-2K-encoded alloantigens.

作者信息

Tartakovsky B, de Baetselier P, Feldman M, Segal S

出版信息

Transplantation. 1983 Aug;36(2):191-7. doi: 10.1097/00007890-198308000-00017.

DOI:10.1097/00007890-198308000-00017

Abstract

Alloantibodies against the H-2b haplotype were produced in C3HeB female and male parental mice in response to transplantation of F1 fetal tissue (bones). In testing IgG1 and IgG2 antibodies by means of the FACS II we found striking sex-associated differences in the isotypes produced: female mice produced much more IgG1 than male mice, although they produced comparable amounts of IgG2. Using protein-A-sepharose-purified fractions of IgG1 and IgG2, raised in the parental females we found the specificity of this extra IgG1 to be directed against the H-2Kb private determinants, in contrast to the IgG2 which was found to be specific for H-2Kb, H-2Db and I-Ab subregion alloantigens. The relevance of the association between H-2K alloantigens and IgG1, in context of the fetal-maternal relationship is discussed.

摘要

针对H-2b单倍型的同种抗体是在C3HeB雌性和雄性亲代小鼠中产生的，这是对F1胎儿组织（骨骼）移植的反应。在通过FACS II检测IgG1和IgG2抗体时，我们发现所产生的同种型存在明显的性别相关差异：雌性小鼠产生的IgG1比雄性小鼠多得多，尽管它们产生的IgG2量相当。使用在亲代雌性小鼠中产生的经蛋白A-琼脂糖纯化的IgG1和IgG2组分，我们发现这种额外IgG1的特异性针对H-2Kb私有决定簇，而IgG2被发现对H-2Kb、H-2Db和I-Ab亚区域同种抗原具有特异性。本文讨论了在胎儿-母体关系背景下H-2K同种抗原与IgG1之间关联的相关性。