Tartakovsky B, De Baetselier P, Feldman M, Segal S
Transplantation. 1981 Nov;32(5):395-7. doi: 10.1097/00007890-198111000-00011.
Alloantibodies against H-2b and H-2k haplotypes were produced in C57BL/6J and C3H female and male mice in response to transplantation of F1 fetal tissue (bone) or adult F1 cells (spleen). Testing IgG1 and IgG2 antibodies by means of the fluorescence-activated cell sorter (FACS II), we found no differences between males and females in the isotype content of antisera produced against spleen cells from adult donors. In contrast, striking sex-associated differences were found in the isotypes produced against fetal allografts: females produced much more IgG1 than males, although they produced comparable amounts of IgG2. Hence, it appears that females differ from males in their humoral alloreactivity against major histocompatibility complex (MHC) gene products expressed on fetal cells. Such MHC antigens expressed on fetal tissues seem to generate different immune signals than the MHC antigens expressed on adult cells. These observations might be of relevance to the biological role played by the IgG1 alloantibodies produced during pregnancy against the MHC alloantigens of the fetus.
针对H-2b和H-2k单倍型的同种抗体是在C57BL/6J和C3H雌性及雄性小鼠体内产生的，这些小鼠是由于移植了F1胎儿组织（骨骼）或成年F1细胞（脾脏）而产生免疫反应。通过荧光激活细胞分选仪（FACS II）检测IgG1和IgG2抗体，我们发现，针对成年供体脾脏细胞产生的抗血清的同种型含量在雄性和雌性之间没有差异。相比之下，在针对胎儿同种异体移植物产生的同种型中发现了显著的性别相关差异：雌性产生的IgG1比雄性多得多，尽管它们产生的IgG2量相当。因此，看来雌性在针对胎儿细胞上表达的主要组织相容性复合体（MHC）基因产物的体液同种异体反应性方面与雄性不同。在胎儿组织上表达的此类MHC抗原似乎产生与成年细胞上表达的MHC抗原不同的免疫信号。这些观察结果可能与孕期产生的针对胎儿MHC同种异体抗原的IgG1同种抗体所起的生物学作用有关。
