Vernon S E, Voet R L
Ultrastruct Pathol. 1983 Mar-Apr;4(2-3):177-86. doi: 10.3109/01913128309140788.
Malignant lymphoma with intracellular immunoglobulins giving a "signet ring" appearance to the lymphocytes is a recently described morphologic variant with specific ultrastructural and immunohistochemical characteristics. We report a case that had this distinctive morphology when initially biopsied but on subsequent biopsy 2 1/2 years later had the typical appearance of a poorly differentiated lymphocytic lymphoma without "signet ring" cells. The same monoclonal immunoglobulin class and light chain type was demonstrated in both biopsies using immunohistochemical techniques. Rare cells in the second biopsy showed the characteristic ultrastructural findings. These findings support the concept of a continuum of cell types in malignant lymphoma, with transformation toward a cell line lacking the peculiar characteristics resulting in this unique appearance.
伴有细胞内免疫球蛋白，使淋巴细胞呈现“印戒”样外观的恶性淋巴瘤是一种最近描述的具有特定超微结构和免疫组织化学特征的形态学变异型。我们报告一例，最初活检时具有这种独特形态，但在2年半后的后续活检中呈现出未分化淋巴细胞淋巴瘤的典型外观，且无“印戒”细胞。使用免疫组织化学技术在两次活检中均检测到相同的单克隆免疫球蛋白类别和轻链类型。第二次活检中的罕见细胞显示出特征性的超微结构表现。这些发现支持了恶性淋巴瘤中细胞类型连续统一体的概念，即向缺乏导致这种独特外观的特殊特征的细胞系转化。
